Pepstatin A

Name: Pepstatin A
Brand: Tocris Bioscience
SKU: 1190
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1190

(1)

Citations (32)

COA / SDS

Selective and high affinity cathepsin D inhibitor

Key Product Details

Description:	Selective and high affinity cathepsin D inhibitor
Purity:	≥95% (HPLC)
Molecular Weight:	685.91

View Full Technical Details for Pepstatin A

Technical Data
Citations / Reviews (1)

Biological Activity for Pepstatin A

Pepstatin A is an irreversible inhibitor of aspartic proteases. Inhibits lysosomal proteases and interferes with autolysosomal digestion when used in combination with E 64d (Cat. No. 4545).

Technical Data for Pepstatin A

M. Wt	685.91
Formula	C₃₄H₆₃N₅O₉
Single Letter Sequence	VVXAX (Modifications: Val-1 = N-terminal iso-Valeryl, X-3 = X-5 = Sta)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	26305-03-3
PubChem ID	5478883
InChi Key	FAXGPCHRFPCXOO-LXTPJMTPSA-N
Smiles	O=C(N[C@@H](CC(C)C)[C@@H](O)CC(N[C@@H](C)C(N[C@H]([C@@H](O)CC(O)=O)CC(C)C)=O)=O)[C@H]([C@@H](C)C)NC([C@@H](NC(CC(C)C)=O)C(C)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Pepstatin A

Solubility

Soluble to 1mg/ml in ethanol with gentle warming

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References for Pepstatin A

References are publications that support the biological activity of the product.

Mizuochi Both cathepsin B and cathepsin D are necessary for processing of ovalbumin as well as for degradation of class II MHC invariant chain. Immunol.Lett. 1997 PMID: 7721331
Sato Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation. Cancer Res. 2007 PMID: 17942897
Gacko Cathepsin D inhibitors. Folia Histochem.Cytobiol. 2007 PMID: 18165168
Marciniszyn Mode of inhibition of acid proteases by pepstatin. J.Biol.Chem. 1976 PMID: 993206