PF 04628935

Name: PF 04628935
Brand: Tocris Bioscience
SKU: 6347

Tocris Bioscience, part of Bio-Techne | Catalog # 6347

COA / SDS

Potent ghrelin receptor inverse agonist

Key Product Details

Description:	Potent ghrelin receptor inverse agonist
Chemical Name:	1-[2-[[2-Chloro-4-(2H-1,2,3-triazol-2-yl)phenyl]methyl]-2,7-diazaspiro[3.5]non-7-yl]-2-(2-methylimidazo[2,1-b]thiazol-6-yl)ethanone
Purity:	≥98% (HPLC)
Molecular Weight:	496.03

View Full Technical Details for PF 04628935

Technical Data
Citations

Biological Activity for PF 04628935

PF 04628935 is a potent ghrelin receptor inverse agonist (IC₅₀ = 4.6 nM). Orally bioavailable and exhibits reasonable brain penetration.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for PF 04628935

PF 04628935 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PF 04628935

M. Wt	496.03
Formula	C₂₄H₂₆ClN₇OS
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1383719-97-8
PubChem ID	70682037
InChi Key	MTDYDDJVCIHZKH-UHFFFAOYSA-N
Smiles	ClC1=C(CN2CC3(CCN(C(CC4=CN(C=C(C)S5)C5=N4)=O)CC3)C2)C=CC(N6N=CC=N6)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PF 04628935

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	24.8	50
	ethanol	9.92	20

Preparing Stock Solutions for PF 04628935

The following data is based on the product molecular weight 496.03.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.03 mL	20.16 mL	40.32 mL
2.5 mM	0.81 mL	4.03 mL	8.06 mL
5 mM	0.40 mL	2.02 mL	4.03 mL
25 mM	0.08 mL	0.40 mL	0.81 mL

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References for PF 04628935

References are publications that support the biological activity of the product.

Kung Identification of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor. Bioorg.Med.Chem.Lett. 2012 PMID: 22677316