PF 04671536 hydrochloride

Name: PF 04671536 hydrochloride
Brand: Tocris Bioscience
SKU: 6024

Tocris Bioscience, part of Bio-Techne | Catalog # 6024

COA / SDS

Potent and selective PDE8B/8A inhibitor

Key Product Details

Description:	Potent and selective PDE8B/8A inhibitor
Chemical Name:	5-Methyl-3-[[(2R)-4-(2-thiazolylmethyl)-2-morpholinyl]methyl]-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-amine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	382.87

View Full Technical Details for PF 04671536 hydrochloride

Technical Data
Citations

Biological Activity for PF 04671536 hydrochloride

PF 04671536 hydrochloride is a potent and selective PDE8B/8A inhibitor (IC₅₀ values are 1.3 and 1.9 nM, respectively). Exhibits selectivity for PDE8A/B over other PDEs (IC₅₀ values are >10 μM) and a range of other targets. Increases glucose-dependent insulin secretion from human pacreatic islet cells. Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc

Compound Libraries for PF 04671536 hydrochloride

PF 04671536 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PF 04671536 hydrochloride

M. Wt	382.87
Formula	C₁₄H₁₈N₈OS.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	1305116-67-9
PubChem ID	131954582
InChi Key	KNBIGIZPAKPDTF-HNCPQSOCSA-N
Smiles	CC1=NC(N)=C2N=NN(C2=N1)C[C@H]3CN(CCO3)CC4=NC=CS4.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PF 04671536 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	7.66	20 with gentle warming
	DMSO	38.29	100

Preparing Stock Solutions for PF 04671536 hydrochloride

The following data is based on the product molecular weight 382.87.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.61 mL	13.06 mL	26.12 mL
5 mM	0.52 mL	2.61 mL	5.22 mL
10 mM	0.26 mL	1.31 mL	2.61 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for PF 04671536 hydrochloride

References are publications that support the biological activity of the product.

DeNinno Discovery of triazolopyrimidine-based PDE8B inhibitors: exceptionally ligand-efficient and lipophilic ligand-efficient compounds for the treatment of diabetes. Bioorg.Med.Chem.Lett. 2012 PMID: 22858141