PF 06281355

Name: PF 06281355
Brand: Tocris Bioscience
SKU: 6004

Tocris Bioscience, part of Bio-Techne | Catalog # 6004

COA / SDS

Selective myeloperoxidase (MPO) inhibitor

Key Product Details

Description:	Selective myeloperoxidase (MPO) inhibitor
Chemical Name:	6-(2,5-Dimethoxyphenyl)-3,4-dihydro-4-oxo-2-thioxo-1(2H)-pyrimidineacetamide
Purity:	≥98% (HPLC)
Molecular Weight:	321.35

View Full Technical Details for PF 06281355

Technical Data
Citations

Biological Activity for PF 06281355

PF 06281355 is a selective myeloperoxidase (MPO) inhibitor (IC₅₀ = 1.5 μM in LPS-stimulated human whole blood). Selective for MPO over a panel of 50 receptors, enzymes, ion channels and transporters, including thyroid peroxidase. Inhibits MPO activity in peritoneal lavage and plasma in a murine peritonitis model. Also reduces lung edema in a murine pulmonary immune complex vasculitis model. Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc

Technical Data for PF 06281355

M. Wt	321.35
Formula	C₁₄H₁₅N₃O₄S
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	1435467-38-1
PubChem ID	71568997
InChi Key	LJBUZOGABRDGBR-UHFFFAOYSA-N
Smiles	COC1=CC(C2=CC(NC(N2CC(N)=O)=S)=O)=C(C=C1)OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PF 06281355

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	6.43	20 with gentle warming

Preparing Stock Solutions for PF 06281355

The following data is based on the product molecular weight 321.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	15.56 mL	77.80 mL	155.59 mL
1 mM	3.11 mL	15.56 mL	31.12 mL
2 mM	1.56 mL	7.78 mL	15.56 mL
10 mM	0.31 mL	1.56 mL	3.11 mL

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References for PF 06281355

References are publications that support the biological activity of the product.

Ruggeri Discovery of 2-(6-(5-chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A highly selective mechanism-based myeloperoxidase inhibitor for the treatment of cardiovascular diseases. J.Med.Chem. 2015 PMID: 26509551
Zheng PF-1355, a mechanism-based myeloperoxidase inhibitor, prevents immune complex vasculitis and anti-glomerular basement membrane glomerulonephritis. J.Pharmacol.Exp.Ther. 2015 PMID: 25698787