PF 06726304 acetate

Name: PF 06726304 acetate
Brand: Tocris Bioscience
SKU: 6169

Tocris Bioscience, part of Bio-Techne | Catalog # 6169

Citations (1)

COA / SDS

Highly potent and SAM-competitive EZH2 inhibitor

Key Product Details

Chemical Name:	5,8-Dichloro-2-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-7-(3,5-dimethyl-4-isoxazolyl)-3,4-dihydro-1(2H)-isoquinolinone acetate
Purity:	≥97%

View Full Technical Details for PF 06726304 acetate

Technical Data
Citations

Biological Activity for PF 06726304 acetate

PF 06726304 acetate is a highly potent and SAM-competitive EZH2 lysine methyltransferase inhibitor (IC₅₀ = 0.7 nM). Inhibits proliferation of Karpas-422 cells (non-Hodgkin's lymphoma) in vitro, and halts tumor growth and reduces intratumoral H3K27Me3 levels in mice.

Technical Data for PF 06726304 acetate

Formula	C₂₂H₂₁Cl₂N₃O₃.C₂H₄O₂
Storage	Store at RT
Purity	≥97%
CAS Number	2080306-28-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PF 06726304 acetate

Solubility

Soluble Soluble to 100 mM in DMSO and to 100 mM in ethanol

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for PF 06726304 acetate

References are publications that support the biological activity of the product.

Kung et al. Design and synthesis of pyridone-containing 3,4-dihydroisoquinoline-1(2H)-ones as a novel class of enhancer of zeste homolog 2 (EZH2) inhibitors. J.Med.Chem., 2016;59:8306 PMID: 27512831

PF 06726304 acetate

Tocris Bioscience, part of Bio-Techne | Catalog # 6169

Key Product Details

Biological Activity for PF 06726304 acetate

Technical Data for PF 06726304 acetate

Solubility for PF 06726304 acetate

Dilution Calculator

Reconstitution Calculator

References for PF 06726304 acetate

Product Documents for PF 06726304 acetate

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

保持关注