PF 431396

Name: PF 431396
Brand: Tocris Bioscience
SKU: 4278

Tocris Bioscience, part of Bio-Techne | Catalog # 4278

Citations (30)

COA / SDS

Dual FAK/PYK2 inhibitor

Key Product Details

Description:	Dual FAK/PYK2 inhibitor
Chemical Name:	N-Methyl-N-[2-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]methanesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	506.5

View Full Technical Details for PF 431396

Technical Data
Citations

Biological Activity for PF 431396

PF 431396 is a dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC₅₀ values are 2 and 11 nM respectively). Promotes osteoblast recruitment and activity, and stimulates bone formation in ovariectomized rats.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for PF 431396

PF 431396 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for PF 431396

M. Wt	506.5
Formula	C₂₂H₂₁F₃N₆O₃S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	717906-29-1
PubChem ID	11598628
InChi Key	POJZIZBONPAWIV-UHFFFAOYSA-N
Smiles	O=C2NC1=CC=C(NC3=NC=C(C(F)(F)F)C(NCC4=CC=CC=C4N(C)S(=O)(C)=O)=N3)C=C1C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PF 431396

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	25.32	50

Preparing Stock Solutions for PF 431396

The following data is based on the product molecular weight 506.5.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.95 mL	19.74 mL	39.49 mL
2.5 mM	0.79 mL	3.95 mL	7.90 mL
5 mM	0.39 mL	1.97 mL	3.95 mL
25 mM	0.08 mL	0.39 mL	0.79 mL

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References for PF 431396

References are publications that support the biological activity of the product.

Han Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design. J.Biol.Chem. 2009 PMID: 19244237
Allen Emerging targets in osteoporosis disease modification. J.Med.Chem. 2010 PMID: 20218623
Buckbinder Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis. Proc.Natl.Acad.Sci.USA 2007 PMID: 17537919