PF 4800567 hydrochloride

Name: PF 4800567 hydrochloride
Brand: Tocris Bioscience
SKU: 4281

Tocris Bioscience, part of Bio-Techne | Catalog # 4281

Citations (2)

COA / SDS

Selective casein kinase 1ε inhibitor

Key Product Details

Description:	Selective casein kinase 1ε inhibitor
Chemical Name:	3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	396.27

View Full Technical Details for PF 4800567 hydrochloride

Technical Data
Citations

Biological Activity for PF 4800567 hydrochloride

PF 4800567 hydrochloride is a selective casein kinase 1ε inhibitor; displays 22-fold greater potency towards CK1ε than CK1δ (IC₅₀ values are 32 and 711 nM for CK1ε and CK1δ respectively). ATP competitive. Displays minimal effect on the circadian clock.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for PF 4800567 hydrochloride

PF 4800567 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of PF 4800567 is reviewed on the chemical probes website.

Technical Data for PF 4800567 hydrochloride

M. Wt	396.27
Formula	C₁₇H₁₈ClN₅O₂.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	1391052-28-0
PubChem ID	71751553
InChi Key	QZXZQMUZEHTFHD-UHFFFAOYSA-N
Smiles	NC1=C(C(COC4=CC(Cl)=CC=C4)=NN2C3CCOCC3)C2=NC=N1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PF 4800567 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	39.63	100

Preparing Stock Solutions for PF 4800567 hydrochloride

The following data is based on the product molecular weight 396.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.52 mL	12.62 mL	25.24 mL
5 mM	0.50 mL	2.52 mL	5.05 mL
10 mM	0.25 mL	1.26 mL	2.52 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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References for PF 4800567 hydrochloride

References are publications that support the biological activity of the product.

Etchegaray Casein kinase 1 delta (CK1δ) regulates period length of the mouse suprachiasmatic circadian clock in vitro. PLoS One 2010 PMID: 20421981
Meng Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes. Proc.Natl.Acad.Sci.USA 2010 PMID: 20696890
Walton Selective inhibition of casein kinase 1ε minimally alters circadian clock period. J.Pharmacol.Exp.Ther. 2009 PMID: 19458106