PFI 3

Name: PFI 3
Brand: Tocris Bioscience
SKU: 5072

Tocris Bioscience, part of Bio-Techne | Catalog # 5072

Citations (8)

COA / SDS

Potent and selective SMARCA2/4 and polybromo 1 inhibitor

Key Product Details

Chemical Name:	(2E)-1-(2-Hydroxyphenyl)-3-[(1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl]prop-2-en-1-one
Purity:	≥98%

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Technical Data
Citations

Biological Activity for PFI 3

PFI 3 is a potent and selective polybromo 1 (PBRM1) and SMARCA4 inhibitor (K_d values are 48 and 89 nM respectively) that also inhibits SMARCA2. This compoud displays 30-fold selectivity over other sub-family branches. PFI 3 accelerates FRAP recovery in cells at a concentration of 1 μM.

Technical Data for PFI 3

Formula	C₁₉H₁₉N₃O₂
Storage	Store at -20°C
Purity	≥98%
CAS Number	1819363-80-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PFI 3

Solubility

Soluble Soluble to 100 mM in DMSO and to 5 mM in ethanol with gentle warming

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References for PFI 3

References are publications that support the biological activity of the product.

Gerstenberger et al. Identification of a chemical probe for family VIII bromodomains through optimization of a fragment hit. J.Med.Chem., 2016;59:4800 PMID: 27115555
Vangamudi et al. The SMARCA2/4 ATPase domain surpasses the bromodomain as a drug target in SWI/SNF mutant cancers: Insights from cDNA rescue and PFI-3 inhibitor studies Cancer Res., 2015;75:3865 PMID: 26139243

PFI 3

Tocris Bioscience, part of Bio-Techne | Catalog # 5072

Key Product Details

Biological Activity for PFI 3

Technical Data for PFI 3

Solubility for PFI 3

Dilution Calculator

Reconstitution Calculator

References for PFI 3

Product Documents for PFI 3

COA

Certificate of Analysis

SDS

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