Phentolamine Mesylate

Name: Phentolamine Mesylate
Brand: Tocris Bioscience
SKU: 6431

Tocris Bioscience, part of Bio-Techne | Catalog # 6431

Citations (7)

COA / SDS

Adrenergic α receptor antagonist; antihypertensive

Key Product Details

Description:	Adrenergic α receptor antagonist; antihypertensive
Chemical Name:	3-[[(4,5-Dihydro-1H-imidazol-2-yl)methyl](4-methylphenyl)amino]phenol methanesulfonate
Purity:	≥98% (HPLC)
Molecular Weight:	377.46

View Full Technical Details for Phentolamine Mesylate

Technical Data
Citations

Biological Activity for Phentolamine Mesylate

Phentolamine Mesylate is a non-selective adrenergic α receptor antagonist (pKB = 8.07). Intravenous injection causes hypotension and tachycardia in rats. Intraperitoneal injection in mice increases plasma FGF21 levels.

Compound Libraries for Phentolamine Mesylate

Phentolamine Mesylate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Phentolamine Mesylate

M. Wt	377.46
Formula	C₁₇H₁₉N₃O.CH₄O₃S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	65-28-1
PubChem ID	91430
InChi Key	OGIYDFVHFQEFKQ-UHFFFAOYSA-N
Smiles	CS(O)(=O)=O.CC1=CC=C(N(C2=CC(O)=CC=C2)CC3=NCCN3)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Phentolamine Mesylate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	37.75	100
	DMSO	37.75	100

Preparing Stock Solutions for Phentolamine Mesylate

The following data is based on the product molecular weight 377.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.65 mL	13.25 mL	26.49 mL
5 mM	0.53 mL	2.65 mL	5.30 mL
10 mM	0.26 mL	1.32 mL	2.65 mL
50 mM	0.05 mL	0.26 mL	0.53 mL

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References for Phentolamine Mesylate

References are publications that support the biological activity of the product.

Fioretti Renal and femoral venous blood flows are regulated by different mechanisms dependent on α-adrenergic receptor subtypes and nitric oxide in anesthetized rats. Vascul.Pharmacol. 2017 PMID: 28986330
Nonogaki & Kaji α1-adrenergic receptor downregulated hepatic FGF21 production and circulating FGF21 levels in mice. Neurosci.Lett. 2017 PMID: 27939978
Liu & Coupar Evidence for functional alpha 2D-adrenoceptors in the rat intestine. Br.J.Pharmacol. 1996 PMID: 8851491