Phortress

Name: Phortress
Brand: Tocris Bioscience
SKU: 4995

Tocris Bioscience, part of Bio-Techne | Catalog # 4995

Citations (1)

COA / SDS

Prodrug of the antitumor agent 5F 203

Key Product Details

Description:	Prodrug of the antitumor agent 5F 203
Chemical Name:	(2S)-2,6-Diamino-N-[4-(5-fluoro-2-benzothiazolyl)-2-methylphenyl]hexanamide dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	459.41

View Full Technical Details for Phortress

Technical Data
Citations

Biological Activity for Phortress

Phortress is a prodrug of the antitumor agent 5F 203, which acts via binding to aryl hydrocarbon receptors. Induces expression of CYP1A1 and generates adducts in the DNA of sensitive MCF7 and IGROV-1 cells.

Technical Data for Phortress

M. Wt	459.41
Formula	C₂₀H₂₃FN₄OS.2HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	328087-38-3
PubChem ID	9804228
InChi Key	QZSMNTOCJVVFEU-CKUXDGONSA-N
Smiles	FC1=CC=C2C(N=C(C3=CC=C(NC([C@H](CCCCN)N)=O)C(C)=C3)S2)=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Phortress

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO		100

Preparing Stock Solutions for Phortress

The following data is based on the product molecular weight 459.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.18 mL	10.88 mL	21.77 mL
5 mM	0.44 mL	2.18 mL	4.35 mL
10 mM	0.22 mL	1.09 mL	2.18 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Phortress

References are publications that support the biological activity of the product.

Bradshaw and Westwell The development of the antitumour benzothiazole prodrug, phortress, as a clinical candidate. Curr.Med.Chem. 2004 PMID: 15078163
Leong In vitro, in vivo and in silico analyses of the antitumor activity of 2(-4-amino-3-methylphenyl)-5-fluorobenzothiazoles. Mol.Cancer Ther. 2004 PMID: 15634650
Trapani DNA damage and cell cycle arrest induced by 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203, NSC 703786) is attenuated by aryl hydrocarbon receptor deficient MCF-7 cells. Br.J.Cancer 2003 PMID: 12592376
Leong Antitumour 2-(4-aminophenyl)benzothiazoles generate DNA adducts in sensitive tumour cells in vitro and in vivo. Br.J.Cancer 2003 PMID: 12569393