PHPS1 sodium salt

Name: PHPS1 sodium salt
Brand: Tocris Bioscience
SKU: 6771

Tocris Bioscience, part of Bio-Techne | Catalog # 6771

Citations (1)

COA / SDS

Shp2 (PTPN11) inhibitor

Key Product Details

Description:	Shp2 (PTPN11) inhibitor
Chemical Name:	4-[2-[1,5-Dihydro-3-(4-nitrophenyl)-5-oxo-1-phenyl-4H-pyrazol-4-ylidene]hydrazinyl]benzenesulfonic acid sodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	487.42

View Full Technical Details for PHPS1 sodium salt

Technical Data
Citations

Biological Activity for PHPS1 sodium salt

PHPS1 sodium salt is a Shp2 (PTPN11) inhibitor (IC₅₀ = 2.1 μM). Inhibits hepatocyte growth factor-stimulated epithelial cell scattering and branching morphogenesis in vitro. Increases myelin basic protein (MBP) levels in zebrafish embryo spinal cord. Also ameliorates bleomycin-induced pulmonary and dermal fibrosis in vivo.

Technical Data for PHPS1 sodium salt

M. Wt	487.42
Formula	C₂₁H₁₄N₅O₆SNa
Storage	Store at -20°C
Purity	≥98% (HPLC)
PubChem ID	136664438
InChi Key	MNHVHZFYTKWRFD-UHFFFAOYSA-M
Smiles	O=S(C1=CC=C(C=C1)N/N=C2C(N(C3=CC=CC=C3)N=C\2C4=CC=C([N+]([O-])=O)C=C4)=O)(O[Na])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PHPS1 sodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	9.75	20

Preparing Stock Solutions for PHPS1 sodium salt

The following data is based on the product molecular weight 487.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	10.26 mL	51.29 mL	102.58 mL
1 mM	2.05 mL	10.26 mL	20.52 mL
2 mM	1.03 mL	5.13 mL	10.26 mL
10 mM	0.21 mL	1.03 mL	2.05 mL

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References for PHPS1 sodium salt

References are publications that support the biological activity of the product.

Ahrendsen The protein tyrosine phosphatase Shp2 regulates oligodendrocyte differentiation and early myelination and contributes to timely remyelination. J.Neurosci. 2018 PMID: 29217681
Zehender The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis. Nat.Commun. 2018 PMID: 30108215
Hellmuth Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking. Proc.Natl.Acad.Sci.U.S.A 2008 PMID: 18480264