Piceatannol

Name: Piceatannol
Brand: Tocris Bioscience
SKU: 1554

Tocris Bioscience, part of Bio-Techne | Catalog # 1554

Citations (28)

COA / SDS

Inhibits TNF-induced NF-κB activation

Key Product Details

Description:	Inhibits TNF-induced NF-κB activation
Chemical Name:	4-[(1E)-2-(3,5-Dihydroxyphenyl)ethenyl]-1,2-benzenediol
Purity:	≥98% (HPLC)
Molecular Weight:	244.25

View Full Technical Details for Piceatannol

Technical Data
Citations

Biological Activity for Piceatannol

Piceatannol is an anti-inflammatory, immunomodulatory and antiproliferative agent. Inhibits p56^lck and syk protein tyrosine kinases and inhibits TNF-induced NF-κB activation and gene expression. Synthesis results from conversion of resveratrol (Cat. No. 1418) by cytochrome P450 1B1.

Technical Data for Piceatannol

M. Wt	244.25
Formula	C₁₄H₁₂O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	10083-24-6
PubChem ID	667639
InChi Key	CDRPUGZCRXZLFL-OWOJBTEDSA-N
Smiles	OC1=CC(\C=C\C2=CC(O)=C(O)C=C2)=CC(O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Piceatannol

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	24.43	100
	DMSO	24.43	100

Preparing Stock Solutions for Piceatannol

The following data is based on the product molecular weight 244.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.09 mL	20.47 mL	40.94 mL
5 mM	0.82 mL	4.09 mL	8.19 mL
10 mM	0.41 mL	2.05 mL	4.09 mL
50 mM	0.08 mL	0.41 mL	0.82 mL

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References for Piceatannol

References are publications that support the biological activity of the product.

Potter The cancer preventative agent resveratrol is converted to the anticancer agent piceatannol by the cytochrome P450 enzyme CYP1B1. Br.J.Cancer 2002 PMID: 11875742
Geahlen and McLaughlin Piceatannol (3,4,3',5'-tetrahydroxy-trans-stilbene) is a naturally occurring protein-tyrosine kinase inhibitor. Biochem.Biophys.Res.Commun. 1989 PMID: 2590224
Oliver Inhibition of mast cell FceR1-mediated signalling and effector function by the syk-selective inhibitor, piceatannol. J.Biol.Chem. 1994 PMID: 7961959
Ashikawa Piceatannol inhibits TNF-induced NF-kB activation and NF-kB-mediated gene expression through suppression of IkBa kinase and p65 phosphorylation. J.Immunol. 2002 PMID: 12444159