Picrotoxin

Name: Picrotoxin
Brand: Tocris Bioscience
SKU: 1128
Rating: 5 (4 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1128

(4)

Citations (1095)

COA / SDS

GABAA antagonist

Key Product Details

Description:	GABA_A antagonist
Purity:	≥97% (HPLC)
Molecular Weight:	602.59

View Full Technical Details for Picrotoxin

Technical Data
Citations / Reviews (4)

Biological Activity for Picrotoxin

Picrotoxin is a GABA_A receptor antagonist; potent CNS stimulant.

Technical Data for Picrotoxin

M. Wt	602.59
Formula	C₃₀H₃₄O₁₃
Storage	Store at RT
Purity	≥97% (HPLC)
CAS Number	124-87-8
PubChem ID	6473767
InChi Key	VJKUPQSHOVKBCO-ZYMHLGHZSA-N
Smiles	[H][C@@]12OC([C@@](C1(C(C)=C)[H])([C@@]3(C[C@H]4O[C@]45C(O[C@]2([C@]35C)[H])=O)O)[H])=O.[H][C@@]67OC([C@@](C6(C(C)(O)C)[H])([C@@]8(C[C@H]9O[C@]9%10C(O[C@]7([C@]8%10C)[H])=O)O)[H])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Picrotoxin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	30.13	50 with gentle warming
	DMSO	12.05	20

Preparing Stock Solutions for Picrotoxin

The following data is based on the product molecular weight 602.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.32 mL	16.60 mL	33.19 mL
2.5 mM	0.66 mL	3.32 mL	6.64 mL
5 mM	0.33 mL	1.66 mL	3.32 mL
25 mM	0.07 mL	0.33 mL	0.66 mL

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Reconstitution Calculator

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References for Picrotoxin

References are publications that support the biological activity of the product.

Ette Picrotoxin blockade of inverterbrate glutamate-gated chloride channels: subunit dependence and evidence for binding within the pore. J.Neurochem. 1999 PMID: 9886084
Newland and Cull-Candy On the mechanism of action of picrotoxin on GABA receptor channels in dissociated sympathetic neurones of the rat. J.Physiol. 1992 PMID: 1317428
Dillon Enhancement by GABA of the association rate of picrotoxin and tert-butylbicyclophosphorothionate to the rat cloned α1β2γ2 GABA_A receptor subtype. Br.J.Pharmacol. 1995 PMID: 7582470