Pifithrin-α hydrobromide

Name: Pifithrin-α hydrobromide
Brand: Tocris Bioscience
SKU: 1267
Rating: 5 (3 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1267

(3)

Citations (14)

COA / SDS

p53 inhibitor. Also aryl hydrocarbon receptor agonist

Key Product Details

Description:	p53 inhibitor. Also aryl hydrocarbon receptor agonist
Chemical Name:	1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone hydrobromide
Molecular Weight:	367.3

View Full Technical Details for Pifithrin-α hydrobromide

Technical Data
Citations / Reviews (3)

Biological Activity for Pifithrin-α hydrobromide

Pifithrin-α hydrobromide is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Active in vivo; protects mice from the side-effects of cancer therapy associated with p53 induction. Supresses self-renewal of embryonic stem cells. Also aryl hydrocarbon receptor (AHR) agonist, causes upregulation of AHR target gene CYP1A1 (EC₅₀ = 1.1 μM). Cyclic analog available (Cat. No. 3843).

Technical Data for Pifithrin-α hydrobromide

M. Wt	367.3
Formula	C₁₆H₁₈N₂OS.HBr
Storage	Desiccate at -20°C
CAS Number	63208-82-2
PubChem ID	9929138
InChi Key	HAGVCKULCLQGRF-UHFFFAOYSA-N
Smiles	Br.CC1=CC=C(C=C1)C(=O)CN1C(=N)SC2=C1CCCC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Pifithrin-α hydrobromide

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	36.73	100

Preparing Stock Solutions for Pifithrin-α hydrobromide

The following data is based on the product molecular weight 367.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.72 mL	13.61 mL	27.23 mL
5 mM	0.54 mL	2.72 mL	5.45 mL
10 mM	0.27 mL	1.36 mL	2.72 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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References for Pifithrin-α hydrobromide

References are publications that support the biological activity of the product.

Abdelalim and Tooyama The p53 inhibitor, pifithrin-α, suppresses self-renewal of embryonic stem cells. Biochem.Biophys.Res.Comm. 2012 PMID: 22445757
Komarova and Gudkov Suppression of p53: a new approach to overcome side effects of antitumor therapy. Biochemistry 2000 PMID: 10702639
Hoagland The p53 inhibitor pifithrin-α is a potent agonist of the aryl hydrocarbon receptor. J.Pharmacol.Exp.Ther. 2005 PMID: 15843497
Komarov A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science 1999 PMID: 10481009
Culmsee A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid β-peptide. J.Neurochem. 2001 PMID: 11279278