Pirfenidone

Name: Pirfenidone
Brand: Tocris Bioscience
SKU: 1093

Tocris Bioscience, part of Bio-Techne | Catalog # 1093

Citations (14)

COA / SDS

Antifibrotic agent; regulates cytokine levels in vivo

Key Product Details

Description:	Antifibrotic agent; regulates cytokine levels in vivo
Chemical Name:	5-methyl-1-phenyl-2(1H)-pyridinone
Purity:	≥99% (HPLC)
Molecular Weight:	185.23

View Full Technical Details for Pirfenidone

Technical Data
Citations

Biological Activity for Pirfenidone

Pirfenidone is a antifibrotic agent, effective in models of pulmonary and lung fibrosis. Inhibits collagen production and fibroblast proliferation. Regulates cytokine levels following oral administration in vivo. Potent scavenger of free radicals and inhibitor of lipid peroxidation.

Technical Data for Pirfenidone

M. Wt	185.23
Formula	C₁₂H₁₁NO
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	53179-13-8
PubChem ID	40632
InChi Key	ISWRGOKTTBVCFA-UHFFFAOYSA-N
Smiles	CC1=CN(C(=O)C=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Pirfenidone

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	3.7	20

Preparing Stock Solutions for Pirfenidone

The following data is based on the product molecular weight 185.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	26.99 mL	134.97 mL	269.93 mL
1 mM	5.40 mL	26.99 mL	53.99 mL
2 mM	2.70 mL	13.50 mL	26.99 mL
10 mM	0.54 mL	2.70 mL	5.40 mL

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References for Pirfenidone

References are publications that support the biological activity of the product.

Oku Pirfenidone suppresses tumor necrosis factor-α, enhances interleukin-10 and protects mice from endotoxic shock. Eur.J.Pharmacol. 2002 PMID: 12098599
Kehrer and Margolin Pirfenidone diminishes cyclophosphamide-induced lung fibrosis in mice. Toxicol.Lett. 1997 PMID: 9067480
Mei Protection of pirfenidone against an early phase of oleic acid-induced acute lung injury in rats. J.Pharmacol.Exp.Ther. 2005 PMID: 15608079
Iyer Effects of pirfenidone on procollagen gene expression at the transcriptional level in bleo. hamster model of lung fibrosis. J.Pharmacol.Exp.Ther. 1999 PMID: 10087006