Pitavastatin calcium

Name: Pitavastatin calcium
Brand: Tocris Bioscience
SKU: 4942

Tocris Bioscience, part of Bio-Techne | Catalog # 4942

Citations (1)

COA / SDS

HMG-CoA reductase inhibitor

Key Product Details

Description:	HMG-CoA reductase inhibitor
Alternative Names:	NK-104
Chemical Name:	(3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid hemicalcium salt
Purity:	≥99% (HPLC)
Molecular Weight:	440.5

View Full Technical Details for Pitavastatin calcium

Technical Data
Citations

Biological Activity for Pitavastatin calcium

Pitavastatin calcium is a synthetic inhibitor of HMG-CoA reductase (K_i = 1.7 nM). Lowers low-density lipoprotein (LDL) cholesterol levels. Displays minimal metabolism by cytochrome P450 enzymes, with little involvement of CYP3A4. Shown to improve cardiac function and survival in a rat model of hypertensive heart failure.

Compound Libraries for Pitavastatin calcium

Pitavastatin calcium is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Pitavastatin calcium

M. Wt	440.5
Formula	C₂₅H₂₃FNO₄.0.5Ca
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	147526-32-7
PubChem ID	5282451
InChi Key	RHGYHLPFVJEAOC-FFNUKLMVSA-L
Smiles	[Ca++].O[C@H](C[C@H](O)\C=C\C1=C(C2=CC=C(F)C=C2)C2=CC=CC=C2N=C1C1CC1)CC([O-])=O.O[C@H](C[C@H](O)\C=C\C1=C(C2=CC=C(F)C=C2)C2=CC=CC=C2N=C1C1CC1)CC([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Pitavastatin calcium

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	44.05	100

Preparing Stock Solutions for Pitavastatin calcium

The following data is based on the product molecular weight 440.5.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.27 mL	11.35 mL	22.70 mL
5 mM	0.45 mL	2.27 mL	4.54 mL
10 mM	0.23 mL	1.14 mL	2.27 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

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Reconstitution Calculator

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References for Pitavastatin calcium

References are publications that support the biological activity of the product.

Mukhtar Pitavastatin. Int.J.Clin.Pract. 2005 PMID: 15854203
Aoki Pharmacological profile of a novel synthetic inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Arzneimittelforschung. 1997 PMID: 9296275
Saka Pitavastatin improves cardiac function and survival in association with suppression of the myocardial endothelin system in a rat model of hypertensive heart failure. J.Cardiovasc.Pharmacol. 2006 PMID: 16810078