PK 44 phosphate

Name: PK 44 phosphate
Brand: Tocris Bioscience
SKU: 4145

Tocris Bioscience, part of Bio-Techne | Catalog # 4145

COA / SDS

Potent and selective dipeptidyl peptidase IV (DPP-IV) inhibitor

Discontinued Product

4145 has been discontinued. View all DPPIV/CD26 Inhibitors products.

Key Product Details

Description:	Potent and selective dipeptidyl peptidase IV (DPP-IV) inhibitor
Chemical Name:	(3R)-3-Amino-4-(6,7-difluoro-1H-indazol-3-yl)-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-1-butanone phosphate
Purity:	≥98% (HPLC)
Molecular Weight:	527.34

View Full Technical Details for PK 44 phosphate

Technical Data
Citations

Biological Activity for PK 44 phosphate

PK 44 phosphate is a potent inhibitor of dipeptidyl peptidase IV (DPP-IV) (IC₅₀ = 15.8 nM). Displays >1000-fold selectivity for DPP-IV over DPP-8 and DPP-9. Improves glucose tolerance in a mouse oral glucose tolerance assay.

Technical Data for PK 44 phosphate

M. Wt	527.34
Formula	C₁₇H₁₆F₅N₇O.H₃PO₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1017682-66-4
PubChem ID	90488917
InChi Key	IRIGBESJZBGJOS-DDWIOCJRSA-N
Smiles	N[C@@H](CC(N4CC3=NN=C(C(F)(F)F)N3CC4)=O)CC2=NNC1=C(F)C(F)=CC=C12.OP(O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for PK 44 phosphate

References are publications that support the biological activity of the product.

Tozer Indole- and indazole-based inhibitors of dipeptidyl peptidase IV for the treatment of type 2 diabetes. 32nd Annual National Medicinal Chemistry Symposium

PK 44 phosphate

Tocris Bioscience, part of Bio-Techne | Catalog # 4145

Key Product Details

Biological Activity for PK 44 phosphate

Technical Data for PK 44 phosphate

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for PK 44 phosphate

Product Documents for PK 44 phosphate

COA

Certificate of Analysis

SDS

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