PK-THPP

Name: PK-THPP
Brand: Tocris Bioscience
SKU: 5338
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5338

(1)

Citations (9)

COA / SDS

Potent K2P9.1 (TASK-3) channel blocker

Key Product Details

Description:	Potent K_2P9.1 (TASK-3) channel blocker
Chemical Name:	1-[1-[6-[[1,1'-Biphenyl]-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]-4-piperidinyl]-1-butanone
Purity:	≥99% (HPLC)
Molecular Weight:	468.59

View Full Technical Details for PK-THPP

Technical Data
Citations / Reviews (1)

Biological Activity for PK-THPP

PK-THPP is a potent TASK-3 channel blocker (IC₅₀ = 35 and 300 nM for TASK-3 and TASK-1 respectively). Increases breathing rate and induces respiratory alkalosis in rats.

Compound Libraries for PK-THPP

PK-THPP is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PK-THPP

M. Wt	468.59
Formula	C₂₉H₃₂N₄O₂
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	1332454-07-5
PubChem ID	53464059
InChi Key	CJZGRIRZVHNUSM-UHFFFAOYSA-N
Smiles	O=C(C1=CC=C(C2=CC=CC=C2)C=C1)N(C3)CCC4=C3C(N5CCC(C(CCC)=O)CC5)=NC=N4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PK-THPP

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	23.43	50
	1eq. HCl	9.37	20 with gentle warming

Preparing Stock Solutions for PK-THPP

The following data is based on the product molecular weight 468.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.27 mL	21.34 mL	42.68 mL
2.5 mM	0.85 mL	4.27 mL	8.54 mL
5 mM	0.43 mL	2.13 mL	4.27 mL
25 mM	0.09 mL	0.43 mL	0.85 mL

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Reconstitution Calculator

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References for PK-THPP

References are publications that support the biological activity of the product.

Coburn Discovery of a pharmacologically active antagonist of the two-pore-domain potassium channel K2P9.1 (TASK-3). ChemMedChem 2012 PMID: 21916012
Cotten TASK-1 (KCNK3) and TASK-3 (KCNK9) tandem pore potassium channel antagonists stimulate breathing in isoflurane-anesthetized rats. Anesth.Analg. 2013 PMID: 23460565