PKI (5-24)

Name: PKI (5-24)
Brand: Tocris Bioscience
SKU: 6221

Tocris Bioscience, part of Bio-Techne | Catalog # 6221

Citations (7)

COA / SDS

High affinity PKA inhibitor

Key Product Details

Description:	High affinity PKA inhibitor
Purity:	≥95% (HPLC)
Molecular Weight:	2222.4

View Full Technical Details for PKI (5-24)

Technical Data
Citations

Biological Activity for PKI (5-24)

PKI (5-24) is a high affinity PKA inhibitor (K_i = 2.3 nM).

Technical Data for PKI (5-24)

M. Wt	2222.4
Formula	C₉₄H₁₄₈N₃₂O₃₁
Single Letter Sequence	TTYADFIASGRTGRRNAIHD
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	99534-03-9
PubChem ID	102397230
InChi Key	AXOXZJJMUVSZQY-LGGJAOENSA-N
Smiles	[H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(O)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PKI (5-24)

Solubility

Soluble to 1mg/ml in water

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References for PKI (5-24)

References are publications that support the biological activity of the product.

Narayana Crystal structure of a polyhistidine-tagged recombinant catalytic subunit of cAMP-dependent protein kinase complexed with the peptide inhibitor PKI(5-24) and adenosine. Biochemistry 1997 PMID: 9109651
Cheng A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase. J.Biol.Chem. 1986 PMID: 3511044