PKUMDL WQ 2101

Name: PKUMDL WQ 2101
Brand: Tocris Bioscience
SKU: 6580

Tocris Bioscience, part of Bio-Techne | Catalog # 6580

Citations (1)

COA / SDS

Negative allosteric modulator of 3-phosphoglycerate dehydrogenase (PHGDH)

Key Product Details

Description:	Negative allosteric modulator of 3-phosphoglycerate dehydrogenase (PHGDH)
Chemical Name:	2,4-Dihydroxy-N'-(2-hydroxy-5-nitrobenzylidene)benzohydrazide
Purity:	≥98% (HPLC)
Molecular Weight:	317.25

View Full Technical Details for PKUMDL WQ 2101

Technical Data
Citations

Biological Activity for PKUMDL WQ 2101

PKUMDL WQ 2101 is a negative allosteric modulator of phosphoglycerate dehydrogenase (PHGDH) (IC₅₀ = 34.8 μM). Exhibits antitumor activity in vitro in breast cancer cells lines overexpressing PHGDH (EC₅₀ values are 7.7 and 10.8 μM in MDA-MB-468 and HCC-70 cells, respectively). Inhibits growth of MDA-MB-468 xenografts in mice.

Technical Data for PKUMDL WQ 2101

M. Wt	317.25
Formula	C₁₄H₁₁N₃O₆
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	304481-72-9
PubChem ID	6741780
InChi Key	RABUUVVWWJCYEN-UHFFFAOYSA-N
Smiles	OC1=CC(O)=C(C(N/N=C/C2=CC([N+]([O-])=O)=CC=C2O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PKUMDL WQ 2101

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	31.73	100

Preparing Stock Solutions for PKUMDL WQ 2101

The following data is based on the product molecular weight 317.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.15 mL	15.76 mL	31.52 mL
5 mM	0.63 mL	3.15 mL	6.30 mL
10 mM	0.32 mL	1.58 mL	3.15 mL
50 mM	0.06 mL	0.32 mL	0.63 mL

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References for PKUMDL WQ 2101

References are publications that support the biological activity of the product.

Wang Rational design of selective allosteric inhibitors of PHGDH and serine synthesis with anti-tumor activity. Cell Chem.Biol. 2017 PMID: 28042046