PKUMDL WQ 2201

Name: PKUMDL WQ 2201
Brand: Tocris Bioscience
SKU: 6581

Tocris Bioscience, part of Bio-Techne | Catalog # 6581

COA / SDS

Negative allosteric modulator of 3-Phosphoglycerate dehydrogenase (PHGDH)

Key Product Details

Description:	Negative allosteric modulator of 3-Phosphoglycerate dehydrogenase (PHGDH)
Chemical Name:	2-Chloro-4-[5-[[2-[(ethylamino)thioxomethyl]hydrazinylidene]methyl]-2-furanyl]benzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	351.81

View Full Technical Details for PKUMDL WQ 2201

Technical Data
Citations

Biological Activity for PKUMDL WQ 2201

PKUMDL WQ 2201 is a negative allosteric modulator of phosphoglycerate dehydrogenase (PHGDH) (IC₅₀ = 35.7 μM). Displays dose-dependent suppression of cell viability in a range of cancer cell lines. Inhibits tumor growth in a xenograft mouse model.

Technical Data for PKUMDL WQ 2201

M. Wt	351.81
Formula	C₁₅H₁₄ClN₃O₃S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	592474-91-4
PubChem ID	5453153
InChi Key	XPACBFAEZIPDRT-LSCVHKIXSA-N
Smiles	CCNC(N/N=C/C1=CC=C(C2=CC(Cl)=C(C(O)=O)C=C2)O1)=S

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PKUMDL WQ 2201

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	35.18	100

Preparing Stock Solutions for PKUMDL WQ 2201

The following data is based on the product molecular weight 351.81.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.84 mL	14.21 mL	28.42 mL
5 mM	0.57 mL	2.84 mL	5.68 mL
10 mM	0.28 mL	1.42 mL	2.84 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

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References for PKUMDL WQ 2201

References are publications that support the biological activity of the product.

Wang Rational design of selective allosteric inhibitors of PHGDH and serine synthesis with anti-tumor activity. Cell Chem.Biol. 2017 PMID: 28042046