PLP (139-151)

Name: PLP (139-151)
Brand: Tocris Bioscience
SKU: 2567

Tocris Bioscience, part of Bio-Techne | Catalog # 2567

Citations (2)

COA / SDS

Encephalitogenic myelin proteolipid fragment

Key Product Details

Description:	Encephalitogenic myelin proteolipid fragment
Alternative Names:	Proteolipid protein (139-151)
Purity:	≥95% (HPLC)
Molecular Weight:	1521.74

View Full Technical Details for PLP (139-151)

Technical Data
Citations

Biological Activity for PLP (139-151)

PLP (139-151) is a synthetic myelin proteolipid protein (PLP) fragment. Immunization with this peptide induces severe clinical and histological experimental allergic encephalomyelitis (EAE), an animal model of multiple sclerosis.

Technical Data for PLP (139-151)

M. Wt	1521.74
Formula	C₇₂H₁₀₄N₂₀O₁₇
Single Letter Sequence	HSLGKWLGHPDKF
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	122018-58-0
PubChem ID	16199055
InChi Key	UQIBUOXNUPHALR-UVIWMAFZSA-N
Smiles	[H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PLP (139-151)

Solubility

Soluble to 2mg/ml in water

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References for PLP (139-151)

References are publications that support the biological activity of the product.

Sobel Acute experimental allergic encephalomyelitis in SJL/J mice induced by a synthetic peptide of myelin proteolipid protein. J.Neuropathol.Exp.Neurol. 1990 PMID: 2273404
Kuchroo Induction of experimental allergic encephalomyelitis by myelin proteolipid-protein-specific T cell clones and synthetic peptides. Pathobiology. 1991 PMID: 1716908
Tuohy Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice. J.Immunol. 1989 PMID: 2465343