PP 242

Biological Activity for PP 242

Technical Data for PP 242

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PP 242

References for PP 242

References are publications that support the biological activity of the product.

• E Jacquin, S Leclerc-Me, C Judon, E Blanchard, S Fraitag, O Florey Pharmacological modulators of autophagy activate a parallel noncanonical pathway driving unconventional LC3 lipidation Autophagy, 2017;0(0):1-14. 2017 PMID: 28296541
• Engels M, Rajarajan K, Feistritzer R, Sharma A, Nielsen U, Schalij M, de Vries A, Pijnappels D, Wu S Insulin-like growth factor promotes cardiac lineage induction in vitro by selective expansion of early mesoderm. Stem Cells, 2014;32(6):1493-502. 2014 PMID: 24496962
• Zhao et al. mTOR complex 2 is involved in regulation of Cbl-dependent c-FLIP regulation and sensitivity of TRAIL-induced apoptosis. Cancer Res., 2013;73:1946 PMID: 23319802
• Apsel et al. Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat.Chem.Biol., 2008;4:691 PMID: 18849971
• Janes et al. Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor. Nat.Med., 2010;16:205 PMID: 20072130