PPTN hydrochloride

Name: PPTN hydrochloride
Brand: Tocris Bioscience
SKU: 4862
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4862

(1)

Citations (7)

COA / SDS

High affinity and selective P2Y14 antagonist

Key Product Details

Description:	High affinity and selective P2Y₁₄ antagonist
Chemical Name:	4-[4-(4-Piperidinyl)phenyl]-7-[4-(trifluoromethyl)phenyl]-2-naphthalenecarboxylic acid hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	511.96

View Full Technical Details for PPTN hydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for PPTN hydrochloride

PPTN hydrochloride is a high affinity and selective P2Y₁₄ antagonist (K_B = 434 pM), which exhibits >10,000-fold selectivity for P2Y₁₄ over other P2Y receptors. PPTN inhibits UDP-glucose and MRS 2690-induced porcine pancreatic artery contraction ex vivo, and also blocks UDP-glucose-induced chemotaxis of HL-60 leukemia cells in vitro.

Compound Libraries for PPTN hydrochloride

PPTN hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

External Portal Information

The Chemical Probes pages of the Structural Genomics Consortium website are a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of PPTN is reviewed.

Technical Data for PPTN hydrochloride

M. Wt	511.96
Formula	C₂₉H₂₄F₃NO₂.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1992047-65-0
PubChem ID	121513852
InChi Key	FKMVYPCBLWYNAV-UHFFFAOYSA-N
Smiles	FC(F)(F)C(C=C4)=CC=C4C1=CC=C(C(C3=CC=C(C5CCNCC5)C=C3)=CC(C(O)=O)=C2)C2=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PPTN hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	51.2	100
	ethanol	10.24	20

Preparing Stock Solutions for PPTN hydrochloride

The following data is based on the product molecular weight 511.96.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.95 mL	9.77 mL	19.53 mL
5 mM	0.39 mL	1.95 mL	3.91 mL
10 mM	0.20 mL	0.98 mL	1.95 mL
50 mM	0.04 mL	0.20 mL	0.39 mL

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Reconstitution Calculator

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References for PPTN hydrochloride

References are publications that support the biological activity of the product.

Alsaqati Novel vasocontractile role of the P2Y₁₄ receptor: characterization of its signalling in porcine isolated pancreatic arteries. Br.J.Pharmacol. 2014 PMID: 24138077
Barrett A selective high-affinity antagonist of the P2Y₁₄ receptor inhibits UDP-glucose-stimulated chemotaxis of human neutrophils. Mol.Pharmacol. 2013 PMID: 23592514
Gao The role of P2Y₁₄ and other P2Y receptors in degranulation of human LAD2 mast cells. Purinergic Signal. 2013 PMID: 22825617