PPTN hydrochloride

Name: PPTN hydrochloride
Brand: Tocris Bioscience
SKU: 4862

Tocris Bioscience, part of Bio-Techne | Catalog # 4862

(1)

Citations (7)

COA / SDS

High affinity and selective P2Y14 antagonist

Key Product Details

Chemical Name:	4-[4-(4-Piperidinyl)phenyl]-7-[4-(trifluoromethyl)phenyl]-2-naphthalenecarboxylic acid hydrochloride
Purity:	≥98%

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Technical Data
Citations / Reviews (1)

Biological Activity for PPTN hydrochloride

PPTN hydrochloride is a high affinity and selective P2Y₁₄ antagonist (K_B = 434 pM), which exhibits >10,000-fold selectivity for P2Y₁₄ over other P2Y receptors. PPTN inhibits UDP-glucose and MRS 2690-induced porcine pancreatic artery contraction ex vivo, and also blocks UDP-glucose-induced chemotaxis of HL-60 leukemia cells in vitro.

Technical Data for PPTN hydrochloride

Formula	C₂₉H₂₄F₃NO₂.HCl
Storage	Store at -20°C
Purity	≥98%
CAS Number	1992047-65-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PPTN hydrochloride

Solubility

Soluble Soluble to 100 mM in DMSO and to 20 mM in ethanol

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References for PPTN hydrochloride

References are publications that support the biological activity of the product.

Alsaqati et al. Novel vasocontractile role of the P2Y₁₄ receptor: characterization of its signalling in porcine isolated pancreatic arteries. Br.J.Pharmacol., 2014;171:701 PMID: 24138077
Barrett et al. A selective high-affinity antagonist of the P2Y₁₄ receptor inhibits UDP-glucose-stimulated chemotaxis of human neutrophils. Mol.Pharmacol., 2013;84:41 PMID: 23592514
Gao et al. The role of P2Y₁₄ and other P2Y receptors in degranulation of human LAD2 mast cells. Purinergic Signal., 2013;9:31 PMID: 22825617

PPTN hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 4862

Key Product Details

Biological Activity for PPTN hydrochloride

Technical Data for PPTN hydrochloride

Solubility for PPTN hydrochloride

Dilution Calculator

Reconstitution Calculator

References for PPTN hydrochloride

Product Documents for PPTN hydrochloride

COA

Certificate of Analysis

SDS

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