Pramipexole dihydrochloride

Name: Pramipexole dihydrochloride
Brand: Tocris Bioscience
SKU: 4174

Tocris Bioscience, part of Bio-Techne | Catalog # 4174

Citations (11)

COA / SDS

Selective D3 agonist

Key Product Details

Description:	Selective D₃ agonist
Chemical Name:	(S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	284.25

View Full Technical Details for Pramipexole dihydrochloride

Technical Data
Citations

Biological Activity for Pramipexole dihydrochloride

Pramipexole dihydrochloride is a dopamine receptor agonist exhibiting selectivity for the D₃ receptor (K_i values are 0.5, 3.3, 3.9 and 3.9 nM for D₃, D_2S, D_2L and D₄ receptors respectively). Exhibits negligible affinity for D₁ and D₅ receptors. Displays activity in the treatment of Parkinson's disease.

Compound Libraries for Pramipexole dihydrochloride

Pramipexole dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Pramipexole dihydrochloride

M. Wt	284.25
Formula	C₁₀H₁₇N₃S.2HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	104632-25-9
PubChem ID	119569
InChi Key	QMNWXHSYPXQFSK-KLXURFKVSA-N
Smiles	NC(S2)=NC1=C2C[C@@H](NCCC)CC1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Pramipexole dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	28.43	100
	DMSO	28.43	100

Preparing Stock Solutions for Pramipexole dihydrochloride

The following data is based on the product molecular weight 284.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.52 mL	17.59 mL	35.18 mL
5 mM	0.70 mL	3.52 mL	7.04 mL
10 mM	0.35 mL	1.76 mL	3.52 mL
50 mM	0.07 mL	0.35 mL	0.70 mL

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Reconstitution Calculator

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References for Pramipexole dihydrochloride

References are publications that support the biological activity of the product.

Mierau Pramipexole binding and activation of cloned and expressed DA D2, D3 and D4 receptors. Eur.J.Pharmacol. 1995 PMID: 7664822