Pravastatin sodium salt

Name: Pravastatin sodium salt
Brand: Tocris Bioscience
SKU: 2318

Tocris Bioscience, part of Bio-Techne | Catalog # 2318

Citations (8)

COA / SDS

HMG-CoA reductase inhibitor

Key Product Details

Description:	HMG-CoA reductase inhibitor
Alternative Names:	Eptastatin sodium
Chemical Name:	(βR,δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β,δ,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-1-naphthaleneheptanoic acid monosodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	446.51

View Full Technical Details for Pravastatin sodium salt

Technical Data
Citations

Biological Activity for Pravastatin sodium salt

Pravastatin sodium salt is a water-soluble, competitive inhibitor of 3-hydroxy-3-methyl coenzyme A (HMG-CoA) reductase. Potently blocks cholesterol synthesis in vivo (K_i~ 1 nM) and displays cardioprotective properties.

Compound Libraries for Pravastatin sodium salt

Pravastatin sodium salt is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Pravastatin sodium salt

M. Wt	446.51
Formula	C₂₃H₃₅NaO₇
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	81131-70-6
PubChem ID	16759173
InChi Key	VWBQYTRBTXKKOG-IYNICTALSA-M
Smiles	[Na+].[H][C@@](O)(CC[C@H]1[C@@H](C)C=CC2=C[C@@H](O)C[C@H](OC(=O)[C@@H](C)CC)[C@]12[H])C[C@@H](O)CC([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Pravastatin sodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	44.65	100
	DMSO	44.65	100

Preparing Stock Solutions for Pravastatin sodium salt

The following data is based on the product molecular weight 446.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.24 mL	11.20 mL	22.40 mL
5 mM	0.45 mL	2.24 mL	4.48 mL
10 mM	0.22 mL	1.12 mL	2.24 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

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Reconstitution Calculator

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References for Pravastatin sodium salt

References are publications that support the biological activity of the product.

Hamelin and Turgeon Hydrophilicity/lipophilicity: relevance for the pharmacology and clinical effects of HMG-CoA reductase inhibitors. TiPS 1998 PMID: 9509899

Product Documents for Pravastatin sodium salt

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Pravastatin sodium, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov