PSB 1115

Name: PSB 1115
Brand: Tocris Bioscience
SKU: 2009

Tocris Bioscience, part of Bio-Techne | Catalog # 2009

Citations (497)

COA / SDS

Selective human A2B antagonist; water-soluble

Key Product Details

Description:	Selective human A_2B antagonist; water-soluble
Chemical Name:	4-(2,3,6,7-Tetrahydro-2,6-dioxo-1-propyl-1H-purin-8-yl)-benzenesulfonic acid
Purity:	≥98% (HPLC)
Molecular Weight:	350.35

View Full Technical Details for PSB 1115

Technical Data
Citations

Biological Activity for PSB 1115

PSB 1115 is a highly selective, water-soluble, human A_2B adenosine receptor antagonist. K_i values are 53.4, > 10000 and > 10000 nM at human A_2B, A₁ and A₃ receptors respectively. Also selective versus rat A₁ and A_2A receptors (K_i values are 2200 and 24000 nM respectively). Produces potent analgesic effects in vivo.

Compound Libraries for PSB 1115

PSB 1115 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PSB 1115

M. Wt	350.35
Formula	C₁₄H₁₄N₄O₅S
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	152529-79-8
PubChem ID	5311479
InChi Key	UYDRRQPGDSIMNU-UHFFFAOYSA-N
Smiles	O=C(NC2=C1NC(C3=CC=C(S(=O)(O)=O)C=C3)=N2)N(CCC)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PSB 1115

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	38.84	100
	water	7.77	20 with gentle warming

Preparing Stock Solutions for PSB 1115

The following data is based on the product molecular weight 350.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.85 mL	14.27 mL	28.54 mL
5 mM	0.57 mL	2.85 mL	5.71 mL
10 mM	0.29 mL	1.43 mL	2.85 mL
50 mM	0.06 mL	0.29 mL	0.57 mL

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References for PSB 1115

References are publications that support the biological activity of the product.

Yan and Muller Preparation, properties, reactions, and adenosine receptor affinities of sulfophenylxanthine nitrophenyl esters: toward the development of sulfonic acid prodrugs with peroral bioavailability. J.Med.Chem. 2004 PMID: 14761205
Hayallah 1,8-Disubstituted xanthine derivatives: synthesis of potent A_2B-selective adenosine receptor antagonists. J.Med.Chem. 2002 PMID: 11906291
Abo-Salem Antinociceptive effects of novel A_2B adenosine receptor antagonists. J.Pharmacol.Exp.Ther. 2004 PMID: 14563788
Muller 8-(Sulfostyryl)xanthines: water-soluble A_2A-selective adenosine receptor antagonists. Bioorg.Med.Chem. 1998 PMID: 9681137