PSB CB5

Name: PSB CB5
Brand: Tocris Bioscience
SKU: 6372

Tocris Bioscience, part of Bio-Techne | Catalog # 6372

Citations (3)

COA / SDS

Selective GPR18 antagonist

Key Product Details

Description:	Selective GPR18 antagonist
Chemical Name:	(2Z)-2[[3-[(4-Chlorophenyl)methoxy]phenyl]methylene]-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-3(2H)-one
Purity:	≥98% (HPLC)
Molecular Weight:	384.88

View Full Technical Details for PSB CB5

Technical Data
Citations

Biological Activity for PSB CB5

PSB CB5 is a selective GPR18 antagonist (IC₅₀ = 0.279 μM). Exhibits >36-fold selectivity versus CB₁ and GPR55 and 14-fold selectivity versus CB₂ receptors. Inhibits N-Arachidonylglycine (Cat. No. 1445) induced acrosomal exocytosis in human spermatozoa.

Compound Libraries for PSB CB5

PSB CB5 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PSB CB5

M. Wt	384.88
Formula	C₂₀H₁₇ClN₂O²S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1627710-30-8
PubChem ID	85469571
InChi Key	XJBQRMOGMULGPP-PDGQHHTCSA-N
Smiles	O=C(N1C(SCCC1)=N/2)C2=C\C3=CC(OCC4=CC=C(Cl)C=C4)=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PSB CB5

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	7.7	20

Preparing Stock Solutions for PSB CB5

The following data is based on the product molecular weight 384.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	12.99 mL	64.96 mL	129.91 mL
1 mM	2.60 mL	12.99 mL	25.98 mL
2 mM	1.30 mL	6.50 mL	12.99 mL
10 mM	0.26 mL	1.30 mL	2.60 mL

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References for PSB CB5

References are publications that support the biological activity of the product.

Flegel Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18. Sci.Rep. 2016 PMID: 27572937
Rempel Bicyclic imidazole-4-one derivatives: a new class of antagonists for the orphan G protein-coupled receptors GPR18 and GPR55. Med.Chem.Comm.