Purvalanol A

Name: Purvalanol A
Brand: Tocris Bioscience
SKU: 1580

Tocris Bioscience, part of Bio-Techne | Catalog # 1580

Citations (28)

COA / SDS

Cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5

Key Product Details

Description:	Cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5
Alternative Names:	NG 60
Chemical Name:	(2R)-2-[[6-[(3-Chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol
Purity:	≥98% (HPLC)
Molecular Weight:	388.9

View Full Technical Details for Purvalanol A

Technical Data
Citations

Biological Activity for Purvalanol A

Purvalanol A is a cyclin-dependent kinase (cdk) inhibitor (reported IC₅₀ values are 4, 4 - 70, 75 - 240 and 100 nM for cdk1, cdk2, cdk5 and cdk 7, respectively). Reversibly arrests synchronised cells in G1 and G2, and inhibits cell proliferation and cell death.

Licensing Information

Sold under license from the Regents of the University of California

Compound Libraries for Purvalanol A

Purvalanol A is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Purvalanol A

M. Wt	388.9
Formula	C₁₉H₂₅ClN₆O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	212844-53-6
PubChem ID	456214
InChi Key	PMXCMJLOPOFPBT-HNNXBMFYSA-N
Smiles	ClC1=CC=CC(NC2=C3C(N(C(C)C)C=N3)=NC(N[C@H]([C@@H](C)C)CO)=N2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Purvalanol A

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	19.45	50
	DMSO	38.89	100

Preparing Stock Solutions for Purvalanol A

The following data is based on the product molecular weight 388.9.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.57 mL	12.86 mL	25.71 mL
5 mM	0.51 mL	2.57 mL	5.14 mL
10 mM	0.26 mL	1.29 mL	2.57 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

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References for Purvalanol A

References are publications that support the biological activity of the product.

Jorda How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 2018 PMID: 30234987
Villerbu Cellular effects of purvalanol A: a specific inhibitor of cyclin-dependent kinase activities. Int.J.Cancer 2002 PMID: 11857351
Gray Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science 1998 PMID: 9677190
Gray ATP-site directed inhibitors of cyclin-dependent kinases. Curr.Med.Chem. 1999 PMID: 10495356
Bain The specificities of protein kinase inhibitors: an update. Biochem.J. 2003 PMID: 12534346