Pyrintegrin

Name: Pyrintegrin
Brand: Tocris Bioscience
SKU: 4978

Tocris Bioscience, part of Bio-Techne | Catalog # 4978

Citations (3)

COA / SDS

Enhances survival of human ESCs following enzymatic dissociation

Key Product Details

Description:	Enhances survival of human ESCs following enzymatic dissociation
Chemical Name:	N-(Cyclopropylmethyl)-4-[[4-(3,4-dihydro-6-hydroxy-1(2H)-quinolinyl)-2-pyrimidinyl]amino]benzenesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	451.54

View Full Technical Details for Pyrintegrin

Technical Data
Citations

Biological Activity for Pyrintegrin

Pyrintegrin enhances survival of human embryonic stem cells (hESCs) following enzymatic dissociation. Thought to enhance cell-ECM adhesion and activate integrin signaling. Pyrintegrin increases adhesion of hESCs to matrigel- and laminin-coated plates, but not to gelatin-coated plates. Also podocyte-protective agent and prevents LPS-induced proteinuria in mice.

Compound Libraries for Pyrintegrin

Pyrintegrin is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for Pyrintegrin

M. Wt	451.54
Formula	C₂₃H₂₅N₅O₃S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1228445-38-2
PubChem ID	46223724
InChi Key	QRJTZIJWDLJKQO-UHFFFAOYSA-N
Smiles	OC(C=C3)=CC2=C3N(CCC2)C1=NC(NC4=CC=C(S(NCC5CC5)(=O)=O)C=C4)=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Pyrintegrin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	45.15	100

Preparing Stock Solutions for Pyrintegrin

The following data is based on the product molecular weight 451.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.21 mL	11.07 mL	22.15 mL
5 mM	0.44 mL	2.21 mL	4.43 mL
10 mM	0.22 mL	1.11 mL	2.21 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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Reconstitution Calculator

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References for Pyrintegrin

References are publications that support the biological activity of the product.

Lee A Podocyte-Based Automated Screening Assay Identifies Protective Small Molecules. J.Am.Soc.Nephrol 2015 PMID: 25858967
Xu Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proc.Natl.Acad.Sci.USA 2010 PMID: 20406903