PZM21

Name: PZM21
Brand: Tocris Bioscience
SKU: 7218

Tocris Bioscience, part of Bio-Techne | Catalog # 7218

Citations (1)

COA / SDS

Selective μ receptor agonist

Key Product Details

Description:	Selective μ receptor agonist
Chemical Name:	N-[(2S)-2-(Dimethylamino)-3-(4-hydroxyphenyl)propyl]-N'-[(1S)-1-methyl-2-(3-thienyl)ethyl]urea
Purity:	≥98% (HPLC)
Molecular Weight:	361.5

View Full Technical Details for PZM21

Technical Data
Citations

Biological Activity for PZM21

PZM21 is a selective μ receptor agonist (EC₅₀ = 4.6 nM). PZM21 has been reported to exhibit bias for the G_i signaling pathway over arrestin-3. The compound exhibits 500-fold selectivity for μ over δ receptors and no detectable activity at κ or nociceptin receptors and a panel of 316 other GPCRs. PZM21 induces analgesia in a mouse hot plate assay, but not a tail-flick assay and exhibits no significant conditioned place preference response in in vivo assays. CNS penetrant.

Compound Libraries for PZM21

PZM21 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PZM21

M. Wt	361.5
Formula	C₁₉H₂₇N₃O₂S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1997387-43-5
PubChem ID	121596705
InChi Key	MEDBIJOVZJEMBI-YOEHRIQHSA-N
Smiles	C[C@H](NC(NC[C@@H](N(C)C)CC1=CC=C(C=C1)O)=O)CC2=CSC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PZM21

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	36.15	100
	ethanol	36.15	100

Preparing Stock Solutions for PZM21

The following data is based on the product molecular weight 361.5.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.77 mL	13.83 mL	27.66 mL
5 mM	0.55 mL	2.77 mL	5.53 mL
10 mM	0.28 mL	1.38 mL	2.77 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

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References for PZM21

References are publications that support the biological activity of the product.

Hill The novel μ-opioid receptor agonist PZM21 depresses respiration and induces tolerance to antinociception. Br.J.Pharmacol. 2018 PMID: 29582414
Manglik Structure-based discovery of opioid analgesics with reduced side effects. Nature 2016 PMID: 27533032