QAQ dichloride

Name: QAQ dichloride
Brand: Tocris Bioscience
SKU: 5470

Tocris Bioscience, part of Bio-Techne | Catalog # 5470

Citations (1)

COA / SDS

Photoswitchable Nav, Kv and Cav channel blocker

Key Product Details

Description:	Photoswitchable Na_v, K_v and Ca_v channel blocker
Chemical Name:	2,2'-[1,2-Diazenediylbis(4,1-phenyleneimino)bis[N,N,N-triethyl-2-oxo-ethanaminium] dichloride
Purity:	≥98% (HPLC)
Molecular Weight:	567.59

View Full Technical Details for QAQ dichloride

Technical Data
Citations

Biological Activity for QAQ dichloride

QAQ dichloride is a photoswitchable Na_v, Ca_v and K_v channel blocker. Blocks channels in the trans conformation. Switches conformation from cis to trans at 500 nm and trans to cis at 380 nm. Normally membrane impermeant, but enters nociceptive neurons via ion channels activated by noxious stimuli, particularly TRPV1. Exhibits optically reversible local anesthesia in rats.

Technical Data for QAQ dichloride

M. Wt	567.59
Formula	C₂₈H₄₄Cl₂N₆O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
PubChem ID	91826091
InChi Key	VHURBRSYOFCHNY-UHFFFAOYSA-N
Smiles	O=C(C[N+](CC)(CC)CC)NC(C=C2)=CC=C2/N=N/C1=CC=C(NC(C[N+](CC)(CC)CC)=O)C=C1.[Cl-].[Cl-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for QAQ dichloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	28.38	50

Preparing Stock Solutions for QAQ dichloride

The following data is based on the product molecular weight 567.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.52 mL	17.62 mL	35.24 mL
2.5 mM	0.70 mL	3.52 mL	7.05 mL
5 mM	0.35 mL	1.76 mL	3.52 mL
25 mM	0.07 mL	0.35 mL	0.70 mL

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References for QAQ dichloride

References are publications that support the biological activity of the product.

Banghart MR Photochromic blockers of voltage-gated potassium channels. Angew.Chem.Int.Ed. 2009 PMID: 19882609
Mourot Rapid optical control of nociception with an ion-channel photoswitch. Nat.Methods 2012 PMID: 22343342