Quin C1

Tocris Bioscience, part of Bio-Techne | Catalog # 5583

COA / SDS

Potent and selective FPR2 agonist

Key Product Details

Description:	Potent and selective FPR2 agonist
Chemical Name:	4-Butoxy-N-[1,4-dihydro-2-(4-methoxyphenyl)-4-oxo-3(2H)-quinazolinyl]benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	445.51

View Full Technical Details for Quin C1

Technical Data
Citations

Biological Activity for Quin C1

Quin C1 is a potent and selective FPR2 agonist (EC₅₀ = 15 nM). Induces Ca²⁺ mobilization in FPR2 but not FPR1-transfected mast cells. Induces neutrophil chemotaxis and degranulation in vitro. Reduces neutrophil and lymphocyte counts in bronchoalveolar lavage fluid in a mouse lung injury model. Anti-inflammatory.

Technical Data for Quin C1

M. Wt	445.51
Formula	C₂₆H₂₇N₃O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	786706-21-6
PubChem ID	11751175
InChi Key	XORVAHQXRDLSFT-UHFFFAOYSA-N
Smiles	O=C1N(NC(C2=CC=C(OCCCC)C=C2)=O)C(C3=CC=C(OC)C=C3)NC4=CC=CC=C41

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Quin C1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	44.55	100

Preparing Stock Solutions for Quin C1

The following data is based on the product molecular weight 445.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.24 mL	11.22 mL	22.45 mL
5 mM	0.45 mL	2.24 mL	4.49 mL
10 mM	0.22 mL	1.12 mL	2.24 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Quin C1

References are publications that support the biological activity of the product.

Corminboeuf FPR2/ALXR agonists and the resolution of inflammation. J.Med.Chem. 2014 PMID: 25365541
Zhou Pharmacological characterization of a novel nonpeptide antagonist for formyl peptide receptor-like 1. Mol.Pharmacol. 2007 PMID: 17652444