Quinidine

Name: Quinidine
Brand: Tocris Bioscience
SKU: 4108
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4108

(2)

Citations (15)

COA / SDS

Blocks sodium and potassium channels

Key Product Details

Description:	Blocks sodium and potassium channels
Chemical Name:	(S)-(6-Methoxyquinolin-4-yl)((2R,4S,8R)- 8-vinylquinuclidin-2-yl)methanol hydrochloride
Molecular Weight:	324.42

View Full Technical Details for Quinidine

Technical Data
Citations / Reviews (2)

Biological Activity for Quinidine

Quinidine is a class IA antiarrythmic; reduces both Na⁺ and K⁺ channel currents, including I_Na, I_Kr and I_Ks. Prolongs QT and induces torsade de pointes (TdP).

Technical Data for Quinidine

M. Wt	324.42
Formula	C₂₀H₂₄N₂O₂
Storage	Store at -20°C
CAS Number	56-54-2
PubChem ID	3036746
InChi Key	LOUPRKONTZGTKE-LHFMAAMQSA-N
Smiles	O[C@H](C3N(CC4C=C)CCC4C3)C2=CC=NC1=CC=C(OC)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Quinidine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	32.44	100
	ethanol	8.11	25

Preparing Stock Solutions for Quinidine

The following data is based on the product molecular weight 324.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.08 mL	15.41 mL	30.82 mL
5 mM	0.62 mL	3.08 mL	6.16 mL
10 mM	0.31 mL	1.54 mL	3.08 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

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Reconstitution Calculator

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References for Quinidine

References are publications that support the biological activity of the product.

Borggrefe Short QT syndrome genotype-genotype correlations. J.Electrocardiol. 2005 PMID: 16226079
Wu Role of late sodium current in modulating the proarrhythmic and antiarrhythmic effects of q.dine Heart Rhythm. 2008 PMID: 19084812
Caballero Effects of fleca. and q.dine on Kv4.2 currents: voltage dependence and role of S6 valines. Br.J.Pharmacol. 2003 PMID: 12721103