Quizartinib

Name: Quizartinib
Brand: Tocris Bioscience
SKU: 6788

Tocris Bioscience, part of Bio-Techne | Catalog # 6788

Citations (1)

COA / SDS

Highly potent FLT3 inhibitor

Key Product Details

Description:	Highly potent FLT3 inhibitor
Chemical Name:	N-[5-(1,1-Dimethylethyl)-3-isoxazolyl]-N'-[4-[7-[2-(4-morpholinyl)ethoxy]imidazo[2,1-b]benzothiazol-2-yl]phenyl]urea
Purity:	≥98% (HPLC)
Molecular Weight:	560.67

View Full Technical Details for Quizartinib

Technical Data
Citations

Biological Activity for Quizartinib

Quizartinib is a highly potent FMS-like receptor tyrosine kinase-3 (FLT3) inhibitor (K_d = 1.6 nM, IC₅₀ = 0.56 nM in MV4-11 cell proliferation assay). Displays >10-fold selectivity for FLT3 over panel of 400 kinases. Inhibits FLT3 activity and displays antitumor properties in a mouse MV4-11 tumor xenograft model.

Compound Libraries for Quizartinib

Quizartinib is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for Quizartinib

M. Wt	560.67
Formula	C₂₉H₃₂N₆O₄S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	950769-58-1
PubChem ID	24889392
InChi Key	CVWXJKQAOSCOAB-UHFFFAOYSA-N
Smiles	CC(C)(C1=CC(NC(NC2=CC=C(C3=CN4C(SC5=CC(OCCN6CCOCC6)=CC=C45)=N3)C=C2)=O)=NO1)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Quizartinib

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	56.07	100

Preparing Stock Solutions for Quizartinib

The following data is based on the product molecular weight 560.67.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.78 mL	8.92 mL	17.84 mL
5 mM	0.36 mL	1.78 mL	3.57 mL
10 mM	0.18 mL	0.89 mL	1.78 mL
50 mM	0.04 mL	0.18 mL	0.36 mL

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References for Quizartinib

References are publications that support the biological activity of the product.

Zarrinkar AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML). Blood. 2009 PMID: 19654408
Chao Identification of N-(5-tert-butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea dihydrochloride (AC220), a uniquely potent, selective, and efficacious FMS-like ty J.Med.Chem. 2009 PMID: 19754199