QX 314 chloride

Name: QX 314 chloride
Brand: Tocris Bioscience
SKU: 2313
Rating: 4 (3 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2313

(3)

Citations (71)

COA / SDS

Na+ channel blocker

Key Product Details

Description:	Na⁺ channel blocker
Chemical Name:	N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium chloride
Purity:	≥99% (HPLC)
Molecular Weight:	298.85

View Full Technical Details for QX 314 chloride

Technical Data
Citations / Reviews (3)

Biological Activity for QX 314 chloride

QX 314 chloride is a membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na⁺ channels.

Technical Data for QX 314 chloride

M. Wt	298.85
Formula	C₁₆H₂₇N₂OCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	5369-03-9
PubChem ID	21462
InChi Key	LLPPOMUAOGMYQI-UHFFFAOYSA-N
Smiles	[Cl-].CC[N+](CC)(CC)CC(=O)NC1=C(C)C=CC=C1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for QX 314 chloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	30	100

Preparing Stock Solutions for QX 314 chloride

The following data is based on the product molecular weight 298.85.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.35 mL	16.73 mL	33.46 mL
5 mM	0.67 mL	3.35 mL	6.69 mL
10 mM	0.33 mL	1.67 mL	3.35 mL
50 mM	0.07 mL	0.33 mL	0.67 mL

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Reconstitution Calculator

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References for QX 314 chloride

References are publications that support the biological activity of the product.

Alreja and Aghajanian QX-314 blocks the potassium but not the sodium dependent components of the opiate response in locus coeruleus neurons. Brain Res. 1994 PMID: 8205485
Perkins and Wong Intracellular QX-314 blocks the hyperpolarization activated inward current Iq in hippocampal CA1 pyramidal cells. J.Neurophysiol. 1995 PMID: 7760149
Stichartz The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine. J.Gen.Physiol. 1973 PMID: 4541340