R 715

Tocris Bioscience, part of Bio-Techne | Catalog # 3407

(1)

Citations (24)

COA / SDS

Potent and selective B1 antagonist

Key Product Details

Description:	Potent and selective B₁ antagonist
Purity:	≥95% (HPLC)
Molecular Weight:	1140.35

View Full Technical Details for R 715

Technical Data
Citations / Reviews (1)

Biological Activity for R 715

R 715 is a potent and selective bradykinin B₁ receptor antagonist (pA₂ = 8.49). Displays no activity at B₂ receptors. Reduces mechanical hypernociception in a mouse model of neuropathic pain. Metabolically stable.

Technical Data for R 715

M. Wt	1140.35
Formula	C₅₇H₈₁N₁₃O₁₂
Single Letter Sequence	KRPPGFSXI (Modifications: Lys-1 = N-terminal Ac, X = DβNal)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	185052-09-9
PubChem ID	5311397
InChi Key	DOSXOGUJJBDRGQ-VUBDHFCFSA-N
Smiles	CC[C@H](C)[C@H](NC(=O)[C@@H](CC1=CC2=CC=CC=C2C=C1)NC(=O)[C@H](CO)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(C)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for R 715

Solubility

Soluble to 5mg/ml in water

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References for R 715

References are publications that support the biological activity of the product.

Quintao Neuropathic pain-like behavior after brachial plexus avulsion in mice: the relevance of kinin B₁ and B₂ receptors. J.Neurosci. 2008 PMID: 18337416
Abdouh Retinal plasma extravasation in streptozotocin-diabetic rats mediated by kinin B₁ and B₂ receptors. Br.J.Pharmacol. 2008 PMID: 18311190
Gobeil Structure-activity studies of B₁ receptor-related peptides. Hypertension. 1996 PMID: 8901831