(R)-(+)-Etomoxir sodium salt

Name: ( R )-(+)-Etomoxir sodium salt
Brand: Tocris Bioscience
SKU: 4539
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4539

(4)

Citations (21)

COA / SDS

Carnitine palmitoyltransferase I (CPT1) inhibitor

Key Product Details

Chemical Name:	(R)-(+)-2-[6-(4-Chlorophenoxy)hexyl]-oxirane-2-carboxylic acid sodium salt
Purity:	≥98%

View Full Technical Details for (R)-(+)-Etomoxir sodium salt

Technical Data
Citations / Reviews (4)

Biological Activity for (R)-(+)-Etomoxir sodium salt

(R)-(+)-Etomoxir sodium salt is an inhibitor of carnitine palmitoyltransferase I (CPT1); inhibits β-oxidation in mitochondria. Shown to inhibit cardiolipin biosynthesis from exogenous fatty acid in H9c2 cells.

Technical Data for (R)-(+)-Etomoxir sodium salt

Formula	C₁₅H₁₈ClNaO₄
Storage	Store at -20°C
Purity	≥98%
CAS Number	828934-41-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (R)-(+)-Etomoxir sodium salt

Solubility

Soluble Soluble to 20 mM in water and to 20 mM in DMSO with gentle warming

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References for (R)-(+)-Etomoxir sodium salt

References are publications that support the biological activity of the product.

L Zhang, J Avery, A Yin, AM Singh, TS Cliff, H Yin, S Dalton Generation of Functional Brown Adipocytes from Human Pluripotent Stem Cells via Progression through a Paraxial Mesoderm State Cell Stem Cell, 2020;0(0):. 2020 PMID: 32783886
Christoph Wilhelm, Oliver J Harrison, Vanessa Schmitt, Martin Pelletier, Sean P Spencer, Joseph F Urban, Michelle Ploch, Thirumalai R Ramalinga, Richard M Siegel, Yasmine Belkaid Critical role of fatty acid metabolism in ILC2-mediated barrier protection during malnutrition and helminth infection. The Journal of Experimental Medicine, 2016;0(0):1540-9538. 2016 PMID: 27432938
JC Schell, DR Wisidagama, C Bensard, H Zhao, P Wei, J Tanner, A Flores, J Mohlman, LK Sorensen, CS Earl, KA Olson, R Miao, TC Waller, D Delker, P Kanth, L Jiang, RJ DeBerardin, MP Bronner, DY Li, JE Cox, HR Christofk, WE Lowry, CS Thummel, J Rutter Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism Nat. Cell Biol., 2017;19(9):1027-1036. 2017 PMID: 28812582
Xu et al. Etomoxir mediates differential metabolic channeling of fatty acid and glycerol precursors into cardiolipin in H9c2 cells. J.Lipid Res., 2003;44:415 PMID: 12576524
Agius et al. Stereospecificity of the inhibition of etomoxir of fatty acid and cholesterol synthesis in isolated rat hepatocytes. Biochem.Pharmacol., 1991;42:1717 PMID: 1930298
Rupp et al. Modification of subcellular organelles in pressure-overloaded heart by etomoxir, a carnitine palmitoyltransferase I inhibitor. FASEB J., 1992;6:2349 PMID: 1531968

(R)-(+)-Etomoxir sodium salt

Tocris Bioscience, part of Bio-Techne | Catalog # 4539

Key Product Details

Biological Activity for (R)-(+)-Etomoxir sodium salt

Technical Data for (R)-(+)-Etomoxir sodium salt

Solubility for (R)-(+)-Etomoxir sodium salt

Dilution Calculator

Reconstitution Calculator

References for (R)-(+)-Etomoxir sodium salt

Product Documents for (R)-(+)-Etomoxir sodium salt

COA

Certificate of Analysis

SDS

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