(R)-PFI 2 hydrochloride

Name: ( R )-PFI 2 hydrochloride
Brand: Tocris Bioscience
SKU: 4892

Tocris Bioscience, part of Bio-Techne | Catalog # 4892

Citations (5)

COA / SDS

Potent and selective SETD7 inhibitor

Key Product Details

Chemical Name:	8-Fluoro-1,2,3,4-tetrahydro-N-[(1R)-2-oxo-2-(1-pyrrolidinyl)-1-[[3-(trifluoromethyl)phenyl]methyl]ethyl]-6-isoquinolinesulfonamide hydrochloride
Purity:	≥97%

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Technical Data
Citations

Biological Activity for (R)-PFI 2 hydrochloride

(R)-PFI 2 hydrochloride is a potent and selective SETD7 histone lysine methyltransferase inhibitor (IC₅₀ = 2 nM). Exhibits >1000-fold selectivity over DNMT1 and a panel of 18 other methyltransferases. Inhibits YAP nuclear translocation and function following activation of the Hippo signaling pathway in MCF7 cells.

Negative Control also available.

Technical Data for (R)-PFI 2 hydrochloride

Formula	C₂₃H₂₅F₄N₃O₃S.HCl
Storage	Store at -20°C
Purity	≥97%
CAS Number	1627607-87-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (R)-PFI 2 hydrochloride

Solubility

Soluble Soluble to 100 mM in DMSO and to 20 mM in ethanol with sonication

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References for (R)-PFI 2 hydrochloride

References are publications that support the biological activity of the product.

J Chokpaisar, N Urao, SP Voravuthik, TJ Koh Quercus infectoria inhibits Set7/NF-?B inflammatory pathway in macrophages exposed to a diabetic environment Cytokine, 2017;0(0):. 2017 PMID: 28408068
Scheer et al. A chemical biology toolbox to study protein methyltransferases and epigenetic signaling. Nat.Commun., 2019;10:19 PMID: 30604761
Barsyte-Lovejoy et al. (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells. Proc.Natl.Acad.Sci.U S A, 2014;111:12853 PMID: 25136132

(R)-PFI 2 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 4892

Key Product Details

Biological Activity for (R)-PFI 2 hydrochloride

Technical Data for (R)-PFI 2 hydrochloride

Solubility for (R)-PFI 2 hydrochloride

Dilution Calculator

Reconstitution Calculator

References for (R)-PFI 2 hydrochloride

Product Documents for (R)-PFI 2 hydrochloride

COA

Certificate of Analysis

SDS

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