Rasagiline mesylate

Name: Rasagiline mesylate
Brand: Tocris Bioscience
SKU: 4308

Tocris Bioscience, part of Bio-Techne | Catalog # 4308

Citations (1)

COA / SDS

Selective and irreversible MAO-B inhibitor

Key Product Details

Description:	Selective and irreversible MAO-B inhibitor
Chemical Name:	(1R)-2,3-Dihydro-N-2-propynyl-1H-inden-1-amine methanesulfonate
Purity:	≥99% (HPLC)
Molecular Weight:	267.34

View Full Technical Details for Rasagiline mesylate

Technical Data
Citations

Biological Activity for Rasagiline mesylate

Rasagiline mesylate is a selective irreversible MAO-B inhibitor. Displays antiParkinsonian activity; exhibits neuroprotective and antiapoptotic activity against several neurotoxins in cell culture.

Compound Libraries for Rasagiline mesylate

Rasagiline mesylate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Rasagiline mesylate

M. Wt	267.34
Formula	C₁₂H₁₃N.CH₃SO₃H
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	161735-79-1
PubChem ID	3052775
InChi Key	JDBJJCWRXSVHOQ-UTONKHPSSA-N
Smiles	C#CCN[C@@H]2CCC1=CC=CC=C12.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Rasagiline mesylate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	26.73	100
	DMSO	26.73	100

Preparing Stock Solutions for Rasagiline mesylate

The following data is based on the product molecular weight 267.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.74 mL	18.70 mL	37.41 mL
5 mM	0.75 mL	3.74 mL	7.48 mL
10 mM	0.37 mL	1.87 mL	3.74 mL
50 mM	0.07 mL	0.37 mL	0.75 mL

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References for Rasagiline mesylate

References are publications that support the biological activity of the product.

Maruyama The anti-parkinson drug, rasagiline, prevents apoptotic DNA damage induced by peroxynitrite in human DArgic neuroblastoma SH-SY5Y cells. J.Neural Transm. 2002 PMID: 11956966
Youdim and Weinstock Molecular basis of neuroprotective activities of rasag. and the anti-Alzheimer drug TV3326 [(N-propargyl-(3R)aminoindan-5-YL)-ethyl methyl carbamate]. Cell.Mol.Neurobiol. 2002 PMID: 12043833
Finberg and Youdim Pharmacological properties of the anti-Parkinson drug rasagiline; modification of endogenous brain amines, rese. reversal, serotonergic and DArgic behaviours. Neuropharmacology 2002 PMID: 12504917