Remodelin

Name: Remodelin
Brand: Tocris Bioscience
SKU: 5193

Tocris Bioscience, part of Bio-Techne | Catalog # 5193

COA / SDS

N-acetyltransferase 10 (NAT10) inhibitor

Key Product Details

Description:	N-acetyltransferase 10 (NAT10) inhibitor
Chemical Name:	4-[2-(2-Cyclopentylidenehydrazinyl)-4-thiazolyl]benzonitrile
Purity:	≥99% (HPLC)
Molecular Weight:	282.36

View Full Technical Details for Remodelin

Technical Data
Citations

Biological Activity for Remodelin

Remodelin is a N-acetyltransferase 10 (NAT10) inhibitor. Improves nuclear shape in HGPS (Hutchinson-Gilford progeria syndrome) cells and lamin A/C depleted cells.

Technical Data for Remodelin

M. Wt	282.36
Formula	C₁₅H₁₄N₄S
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	949912-58-7
PubChem ID	44442376
InChi Key	XAEJIFARBQJLML-UHFFFAOYSA-N
Smiles	N#CC(C=C1)=CC=C1C2=CSC(N/N=C3CCCC/3)=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Remodelin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	28.24	100

Preparing Stock Solutions for Remodelin

The following data is based on the product molecular weight 282.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.54 mL	17.71 mL	35.42 mL
5 mM	0.71 mL	3.54 mL	7.08 mL
10 mM	0.35 mL	1.77 mL	3.54 mL
50 mM	0.07 mL	0.35 mL	0.71 mL

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Reconstitution Calculator

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References for Remodelin

References are publications that support the biological activity of the product.

Larrieu Chemical inhibition of NAT10 corrects defects of laminopathic cells. Science 2014 PMID: 24786082