RGD peptide

Name: RGD peptide
Brand: Tocris Bioscience
SKU: 7723

Tocris Bioscience, part of Bio-Techne | Catalog # 7723

Citations (1)

COA / SDS

Minimal recognition sequence for integrin binding; potent integrin inhibitor

Key Product Details

Description:	Minimal recognition sequence for integrin binding; potent integrin inhibitor
Purity:	≥95% (HPLC)
Molecular Weight:	346.34

View Full Technical Details for RGD peptide

Technical Data
Citations

Biological Activity for RGD peptide

RGD peptide is a potent integrin inhibitor (IC₅₀ values are 89, 335 and 440 nM for αvβ3, α5β1 and αvβ5, respectively). RGD is the minimal recognition sequence for integrin binding found in many extracellular matrix (ECM) and serum proteins. RGD peptide is used for directing association of various cell types with diverse biomaterials. The functionality of RGD peptide is usually maintained throughout the processing and sterilization steps required for biomaterials synthesis. RGD peptide can be incorporated into hyaluronic acid hydrogel for human mesenchymal stem cells (hMSCs) delivery. RGD peptide significantly increases hMSC spreading and protein secretion under standard or ischemic culture conditions. RGD peptide can also be incorporated into alginate bioink for 3D bioprinting of MSCs onto cartilage templates for bone organogenesis.

Technical Data for RGD peptide

M. Wt	346.34
Formula	C₁₂H₂₂N₆O₆
Single Letter Sequence	RGD
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	99896-85-2
PubChem ID	104802
InChi Key	IYMAXBFPHPZYIK-BQBZGAKWSA-N
Smiles	O=C(NCC(N[C@@H](CC(O)=O)C(O)=O)=O)[C@H](CCCNC(N)=N)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for RGD peptide

Solubility

Soluble to 10mg/ml in water

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References for RGD peptide

References are publications that support the biological activity of the product.

Daly 3D bioprinting of developmentally inspired templates for whole bone organ engineering. Adv.Healthc.Mater. 2016 PMID: 27281607
Gallagher Pre-culture of mesenchymal stem cells within RGD-modified hyaluronic acid hydrogel improves their resilience to ischaemic conditions. Acta.Biomater. 2020 PMID: 32145393
Ruoslahti New perspectives in cell adhesion: RGD and integrins. Science 1987 PMID: 2821619
Kapp A comprehensive evaluation of the activity and selectivity profile of ligands for RGD-binding integrins. Sci.Rep. 2017 PMID: 28074920
Bellis Advantages of RGD peptides for directing cell association with biomaterials. Biomaterials 2011 PMID: 21515168