Ribociclib

Name: Ribociclib
Brand: Tocris Bioscience
SKU: 7050

Tocris Bioscience, part of Bio-Techne | Catalog # 7050

Citations (2)

COA / SDS

Dual cdk4/cdk6 inhibitor; orally bioavailable

Key Product Details

Description:	Dual cdk4/cdk6 inhibitor; orally bioavailable
Alternative Names:	LEE-011
Chemical Name:	7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	434.54

View Full Technical Details for Ribociclib

Technical Data
Citations

Biological Activity for Ribociclib

Ribociclib is a dual cdk4/cdk6 inhibitor. Induces G₁ phase cell cycle arrest and senescence in neuroblastoma cell lines (IC₅₀ = 306 nM). Delays tumor growth in vivo. Orally bioavailable.

Technical Data for Ribociclib

M. Wt	434.54
Formula	C₂₃H₃₀N₈O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1211441-98-3
PubChem ID	44631912
InChi Key	RHXHGRAEPCAFML-UHFFFAOYSA-N
Smiles	CN(C(C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=CC=C(N5CCNCC5)C=N4)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ribociclib

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	4.35	10

Preparing Stock Solutions for Ribociclib

The following data is based on the product molecular weight 434.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.01 mL	115.06 mL	230.13 mL
0.5 mM	4.60 mL	23.01 mL	46.03 mL
1 mM	2.30 mL	11.51 mL	23.01 mL
5 mM	0.46 mL	2.30 mL	4.60 mL

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Reconstitution Calculator

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References for Ribociclib

References are publications that support the biological activity of the product.

Rader Dual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastoma. Clin. Cancer Res. 2013 PMID: 24045179