Rifampicin

Name: Rifampicin
Brand: Tocris Bioscience
SKU: 4121
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4121

(1)

COA / SDS

Pregnane X receptor agonist; antibiotic

Discontinued Product

4121 has been discontinued. View all Pregnane X Receptor Activators products.

Key Product Details

Description:	Pregnane X receptor agonist; antibiotic
Alternative Names:	Rifampin
Chemical Name:	3-[[(4-Methyl-1-piperazinyl)imino]methyl]-rifamycin
Purity:	≥95% (HPLC)
Molecular Weight:	822.94

View Full Technical Details for Rifampicin

Technical Data
Citations / Reviews (1)

Biological Activity for Rifampicin

Rifampicin is an antibiotic; inhibits bacterial RNA polymerase. Prototypical activator of the pregnane X receptor (PXR).

Technical Data for Rifampicin

M. Wt	822.94
Formula	C₄₃H₅₈N₄O₁₂
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	13292-46-1
PubChem ID	5381226
InChi Key	FZYOVNIOYYPUPY-ZTWDQPHTSA-N
Smiles	CN(CC1)CCN1/N=C/C2=C(O)C3=C(C4=O)C5=C(C)C(O)=C3C(O)=C2NC(/C(C)=C\C=C\[C@H](C)[C@H](O)[C@H]([C@H]([C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)/C=C/O[C@@]4(C)O5)O)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Rifampicin

References are publications that support the biological activity of the product.

Hu Pregnane X receptor is SUMOylated to repress the inflammatory response. J.Pharmacol.Exp.Ther. 2010 PMID: 20719936
Moore Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. J.Biol.Chem. 2000 PMID: 10748001
Artsimovitch Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins. Cell 2005 PMID: 16096056
Wehrli Rifampin: mechanisms of action and resistance. Rev.Infect.Dis. 1983 PMID: 6356275

Product Documents for Rifampicin

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Rifampin, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov