Riluzole hydrochloride

Name: Riluzole hydrochloride
Brand: Tocris Bioscience
SKU: 0768

Tocris Bioscience, part of Bio-Techne | Catalog # 0768

Citations (24)

COA / SDS

GABA uptake inhibitor; also inhibits glutamate release and blocks NaV channels

Key Product Details

Chemical Name:	2-Amino-6-trifluoromethoxybenzothiazole hydrochloride
Purity:	≥98%
Molecular Weight:	270.66 kDa

View Full Technical Details for Riluzole hydrochloride

Technical Data
Citations

Biological Activity for Riluzole hydrochloride

Inhibits glutamate release from presynaptic terminals and increases Na⁺-dependent glutamate uptake in rat cortical synaptosomes. Blocks voltage-dependent Na⁺ channels and inhibits GABA uptake by striatal synaptosomes. Also activates TRPC5 channels. Psychotropic agent with anticonvulsant, hypnotic, anxiolytic, anti-ischemic, anesthetic and neuroprotective properties.

Technical Data for Riluzole hydrochloride

M. Wt	270.66 kDa
Formula	C₈H₅F₃N₂OS.HCl
Storage	Store at RT
Purity	≥98%
CAS Number	850608-87-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Riluzole hydrochloride

Solubility

Soluble Soluble to 100 mM in DMSO and to 10 mM in water with gentle warming

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References for Riluzole hydrochloride

References are publications that support the biological activity of the product.

Fox JT, Sakamuru S, Huang R High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death. Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. 2012 PMID: 22431602
Abushahba W, Olabisi O, Jeong B, Boregowda R, Wen Y, Liu F, Goydos J, Lasfar A, Cohen-Solal K Non-Canonical Smads Phosphorylation Induced by the Glutamate Release Inhibitor, Riluzole, through GSK3 Activation in Melanoma. PLoS ONE, 2012;7(10):e47312. 2012 PMID: 23077590
Taylor and Meldrum Na⁺ channels as targets for neuroprotective drugs. TiPS, 1995;16:309 PMID: 7482996
Fumagalli et al. Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1. Eur.J.Pharmacol., 2008;578:171 PMID: 18036519
Richter et al. Riluzole activates TRPC5 channels independently of PLC activity. Br.J.Pharmacol., 2014;171:158 PMID: 24117252
Song et al. Differential action of Riluzole on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels. J.Pharmacol.Exp.Ther., 1997;282:707 PMID: 9262334
Umeniya and Berger Inhibition by Riluzole of glycinergic postsynaptic currents in rat hypoglossal motoneurones. Br.J.Pharmacol., 1995;116:3227 PMID: 8719800