RITA

Name: RITA
Brand: Tocris Bioscience
SKU: 2443

Tocris Bioscience, part of Bio-Techne | Catalog # 2443

Citations (4)

COA / SDS

MDM2-p53 interaction inhibitor

Key Product Details

Chemical Name:	5,5'-(2,5-Furandiyl)bis-2-thiophenemethanol
Purity:	≥97%

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Technical Data
Citations

Biological Activity for RITA

RITA is an anti-tumor agent that binds wild-type p53 (K_d = 1.5 nM) preventing p53-MDM2 (HDM2) interaction. Induces p53 accumulation and stimulates apoptosis in tumor cell lines expressing wild-type p53 in vitro and in vivo. Inhibits HPV-E6-mediated proteasomal degradation. Suppresses expression of cervical carcinoma HeLa xenografts in vivo.

Technical Data for RITA

Formula	C₁₄H₁₂O₃S₂
Storage	Store at -20°C
Purity	≥97%
CAS Number	213261-59-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for RITA

Solubility

Soluble Soluble to 100 mM in DMSO and to 25 mM in ethanol

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References for RITA

References are publications that support the biological activity of the product.

Rivera et al. Selective toxicity of the tricyclic thiophene NSC 652287 in renal carcinoma cell lines: differential accumulation and metabolism. Biochem.Pharmacol., 1999;57:1283 PMID: 10230772
Zhao et al. Rescue of p53 function by small-molecule RITA in cervical carcinoma by blocking E6-mediated degradation. Cancer Res., 2010;70:3372 PMID: 20395210
Issaeva et al. Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumours. Nature Med., 2004;10:1321
Espinoza-Fonseca Targeting MDM2 by the small molecule RITA: towards the development of new multi-target drugs against cancer. Theor.Biol.Med.Mod., 2005;2:38

RITA

Tocris Bioscience, part of Bio-Techne | Catalog # 2443

Key Product Details

Biological Activity for RITA

Technical Data for RITA

Solubility for RITA

Dilution Calculator

Reconstitution Calculator

References for RITA

Product Documents for RITA

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

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