Ritonavir

Name: Ritonavir
Brand: Tocris Bioscience
SKU: 5856

Tocris Bioscience, part of Bio-Techne | Catalog # 5856

Citations (6)

COA / SDS

HIV-1 and HIV-2 protease inhibitor

Key Product Details

Description:	HIV-1 and HIV-2 protease inhibitor
Alternative Names:	ABT-538,A-84538,Abbot 84538
Chemical Name:	5-Thiazolylmethyl (3S,4S,6S,9S)-4-hydroxy-12-methyl-9-(1-methylethyl)-13-[2-(1-methylethyl)-4-thiazolyl]-8,11-dioxo-3,6-bis(phenylmethyl)-2,7,10,12-tetraazatridecanoate
Purity:	≥98% (HPLC)
Molecular Weight:	720.94

View Full Technical Details for Ritonavir

Technical Data
Citations

Biological Activity for Ritonavir

Ritonavir is a HIV-1 and HIV-2 protease inhibitor (EC₅₀ values are 0.022-0.13 and 0.16 μM, respectively). Blocks the metabolism of protease inhibitors by liver enzyme cytochrome P450-3A4 (CYP3A4). Orally bioavailable. When used in combination with lopinavir, improves outcome in an animal model of MERS-CoV infection.

Compound Libraries for Ritonavir

Ritonavir is also offered as part of the Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Ritonavir

M. Wt	720.94
Formula	C₃₇H₄₈N₆O₅S₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	155213-67-5
PubChem ID	392622
InChi Key	NCDNCNXCDXHOMX-XGKFQTDJSA-N
Smiles	O[C@@H](C[C@@H](NC([C@H](C(C)C)NC(N(C)CC1=CSC(C(C)C)=N1)=O)=O)CC2=CC=CC=C2)[C@@H](NC(OCC3=CN=CS3)=O)CC4=CC=CC=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ritonavir

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	14.42	20 with gentle warming
	ethanol	7.21	10

Preparing Stock Solutions for Ritonavir

The following data is based on the product molecular weight 720.94.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	6.94 mL	34.68 mL	69.35 mL
1 mM	1.39 mL	6.94 mL	13.87 mL
2 mM	0.69 mL	3.47 mL	6.94 mL
10 mM	0.14 mL	0.69 mL	1.39 mL

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Reconstitution Calculator

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References for Ritonavir

References are publications that support the biological activity of the product.

Chan Treatment with Lopinavir/Ritonavir or Interferon-β1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset. J.Infect.Dis. 2015 PMID: 26198719
Kempf Discovery of ritonavir, a potent inhibitor of HIV protease with high oral bioavailability and clinical efficacy. J.Med.Chem. 1998 PMID: 9484509
Zeldin Pharmacological and therapeutic properties of ritonavir-boosted protease inhibitor therapy in HIV-infected patients. J.Antimicrob.Chemother. 2004 PMID: 14657084
Kempf ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans. Proc.Natl.Acad.Sci.U.S.A. 1995 PMID: 7708670