RN 1734

Name: RN 1734
Brand: Tocris Bioscience
SKU: 3746

Tocris Bioscience, part of Bio-Techne | Catalog # 3746

Citations (39)

COA / SDS

Selective TRPV4 antagonist

Key Product Details

Description:	Selective TRPV4 antagonist
Chemical Name:	2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide
Molecular Weight:	353.31

View Full Technical Details for RN 1734

Technical Data
Citations

Biological Activity for RN 1734

RN 1734 is a selective TRPV4 antagonist (IC₅₀ values are 2.3, 3.2 and 5.9 μM for hTRPV4, rTRPV4 and mTRPV4 receptors respectively). Displays selectivity for TRPV4 over other TRP channels (IC₅₀ values are 2.3, >30, >30 and >100 μM for TRPV4, TRPV3, TRPM8 and TRPV1 respectively). Blocks TRPV4-mediated arteriole vasodilation and increases myogenic tone ex vivo.

Compound Libraries for RN 1734

RN 1734 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for RN 1734

M. Wt	353.31
Formula	C₁₄H₂₂Cl₂N₂O₂S
Storage	Store at +4°C
CAS Number	946387-07-1
PubChem ID	3601086
InChi Key	IHYZMEAZAIFMTN-UHFFFAOYSA-N
Smiles	CC(C)NCCN(C(C)C)S(C1=C(Cl)C=C(Cl)C=C1)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for RN 1734

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	35.33	100
	ethanol	17.67	50

Preparing Stock Solutions for RN 1734

The following data is based on the product molecular weight 353.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.83 mL	14.15 mL	28.30 mL
5 mM	0.57 mL	2.83 mL	5.66 mL
10 mM	0.28 mL	1.42 mL	2.83 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

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References for RN 1734

References are publications that support the biological activity of the product.

Bagher Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca2+ events, and IKCa channels, reducing arteriolar tone. Proc.Natl.Acad.Sci.U.S.A. 2012 PMID: 23071308
Vincent Identification and characterization of novel TRPV4 modulators. Biochem.Biophys.Res.Comms. 2009 PMID: 19737537