RN 1734

Name: RN 1734
Brand: Tocris Bioscience
SKU: 3746

Tocris Bioscience, part of Bio-Techne | Catalog # 3746

Citations (39)

COA / SDS

Selective TRPV4 antagonist

Key Product Details

Chemical Name:

2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide

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Technical Data
Citations

Biological Activity for RN 1734

RN 1734 is a selective TRPV4 antagonist (IC₅₀ values are 2.3, 3.2 and 5.9 μM for hTRPV4, rTRPV4 and mTRPV4 receptors respectively). Displays selectivity for TRPV4 over other TRP channels (IC₅₀ values are 2.3, >30, >30 and >100 μM for TRPV4, TRPV3, TRPM8 and TRPV1 respectively). Blocks TRPV4-mediated arteriole vasodilation and increases myogenic tone ex vivo.

Technical Data for RN 1734

Formula	C₁₄H₂₂Cl₂N₂O₂S
Storage	Store at +4°C
CAS Number	946387-07-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for RN 1734

Solubility

Soluble Soluble to 100 mM in DMSO and to 50 mM in ethanol

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References for RN 1734

References are publications that support the biological activity of the product.

RM Samuel, H Majd, MN Richter, Z Ghazizadeh, SM Zekavat, A Navickas, JT Ramirez, H Asgharian, CR Simoneau, LR Bonser, KD Koh, M Garcia-Kni, M Tassetto, S Sunshine, S Farahvashi, A Kalantari, W Liu, R Andino, H Zhao, P Natarajan, DJ Erle, M Ott, H Goodarzi, F Fattahi Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men Cell Stem Cell, 2020;27(6):876-889.e12. 2020 PMID: 33232663
Bagher et al. Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca2+ events, and IKCa channels, reducing arteriolar tone. Proc.Natl.Acad.Sci.U.S.A., 2012;109:18174 PMID: 23071308
Vincent et al. Identification and characterization of novel TRPV4 modulators. Biochem.Biophys.Res.Comms., 2009;389:490 PMID: 19737537

RN 1734

Tocris Bioscience, part of Bio-Techne | Catalog # 3746

Key Product Details

Biological Activity for RN 1734

Technical Data for RN 1734

Solubility for RN 1734

Dilution Calculator

Reconstitution Calculator

References for RN 1734

Product Documents for RN 1734

COA

Certificate of Analysis

SDS

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