RN 1747

Name: RN 1747
Brand: Tocris Bioscience
SKU: 3745

Tocris Bioscience, part of Bio-Techne | Catalog # 3745

Citations (10)

COA / SDS

Selective TRPV4 agonist

Key Product Details

Description:	Selective TRPV4 agonist
Chemical Name:	1-(4-Chloro-2-nitrophenyl)sulfonyl-4-benzylpiperazine
Purity:	≥98% (HPLC)
Molecular Weight:	395.87

View Full Technical Details for RN 1747

Technical Data
Citations

Biological Activity for RN 1747

RN 1747 is a selective TRPV4 agonist (EC₅₀ values are 0.77, 4.0 and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively). Displays selectivity over other TRP channels (EC₅₀ values are 0.77, >30, >30 and >100 μM for TRPV4, TRPM8, TRPV3 and TRPV1 receptors respectively). Also antagonizes TRPM8 at relevant concentrations (IC₅₀ = 4 μM).

Compound Libraries for RN 1747

RN 1747 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for RN 1747

M. Wt	395.87
Formula	C₁₇H₁₈ClN₃O₄S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1024448-59-6
PubChem ID	5068295
InChi Key	ZNLVYSJQUMALEO-UHFFFAOYSA-N
Smiles	ClC1=CC=C(S(N2CCN(CC3=CC=CC=C3)CC2)(=O)=O)C([N+]([O-])=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for RN 1747

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	39.59	100

Preparing Stock Solutions for RN 1747

The following data is based on the product molecular weight 395.87.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.53 mL	12.63 mL	25.26 mL
5 mM	0.51 mL	2.53 mL	5.05 mL
10 mM	0.25 mL	1.26 mL	2.53 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

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References for RN 1747

References are publications that support the biological activity of the product.

Vincent Identification and characterization of novel TRPV4 modulators. Biochem.Biophys.Res.Comms. 2009 PMID: 19737537