Ro 51

Tocris Bioscience, part of Bio-Techne | Catalog # 4391

COA / SDS

Potent P2X3 and P2X2/3 antagonist

Key Product Details

Description:	Potent P2X₃ and P2X_2/3 antagonist
Chemical Name:	2-[[4-Amino-5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinyl]amino]-1,3-propanediol
Purity:	≥98% (HPLC)
Molecular Weight:	474.29

View Full Technical Details for Ro 51

Technical Data
Citations

Biological Activity for Ro 51

Ro 51 is a potent, dual P2X₃ and P2X_2/3 antagonist (IC₅₀ values are 2 and 5 nM for rP2X₃ and hP2X_2/3 respectively). Selective for P2X₃ and P2X_2/3 over other P2X receptors (IC₅₀ values are > 10 μM for P2X₁, P2X₂, P2X₄, P2X₅, and P2X₇). Cell permeable.

Technical Data for Ro 51

M. Wt	474.29
Formula	C₁₇H₂₃IN₄O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1050670-85-3
PubChem ID	24883277
InChi Key	PAYROHWFGZADBR-UHFFFAOYSA-N
Smiles	NC1=NC(NC(CO)CO)=NC=C1OC2=C(C(C)C)C=C(OC)C(I)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Ro 51

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	47.43	100
	ethanol	47.43	100

Preparing Stock Solutions for Ro 51

The following data is based on the product molecular weight 474.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.11 mL	10.54 mL	21.08 mL
5 mM	0.42 mL	2.11 mL	4.22 mL
10 mM	0.21 mL	1.05 mL	2.11 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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Reconstitution Calculator

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References for Ro 51

References are publications that support the biological activity of the product.

Syed and Kennedy Pharmacology of P2X receptors WIREs.Membr.Transp.Signal.
Jahangir Identification and SAR of novel diaminopyrimidines. Part 2: The discovery of RO-51, a potent and selective, dual P2X₃/P2X_2/3 antagonist for the treatment of pain. Bioorg.Med.Chem.Lett. 2009 PMID: 19231178